Evidence map›Paper›PMID 22590699›Full record

ReviewCanadian journal of gastroenterology = Journal canadien de gastroenterologie2012

Management of primary sclerosing cholangitis: conventions and controversies.

Natasha Chandok, Gideon M Hirschfield

Open access · goldAbstract readReview
In one paragraph

Review in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Sex-related factors in autoimmune liver diseases.Seminars in immunopathology · 2019
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Endoscopic management of benign biliary strictures.Current gastroenterology reports · 2015
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Natasha ChandokDivision of Gastroenterology, Western University, London, United Kingdom. chandok.n@gmail.com
Gideon M Hirschfield
University of Birmingham · GBWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy that results in fibrotic strictures and dilations of the intra- and extrahepatic bile ducts. PSC is uncommon, occurs predominantly in males and has a strong association with inflammatory bowel disease. While the pathogenesis of PSC has not been fully elucidated, emerging evidence supports roles for the innate and adaptive immune systems, and genome-wide analyses have identified several genetic associations. Using the best available evidence, the present review summarizes the current understanding of the diagnosis, pathogenesis and management of PSC. Despite its rarity, there is an urgent need for collaborative research efforts to advance therapeutic options for PSC beyond liver transplantation.

Indexed as

AnimalsChemokinesCholagogues and CholereticsCholangiographyCholangiopancreatography, Magnetic ResonanceCholangitis, SclerosingDisease Models, AnimalGenome-Wide Association StudyHumansLiver TransplantationMagnetic Resonance ImagingUrsodeoxycholic AcidChemokinesCholagogues and CholereticsUrsodeoxycholic Acid

Identifiers

PMID22590699
PMCPMC3352841
OpenAlexW1586533841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.