Evidence map›Paper›PMID 22590656›Full record

SynthesisPLoS neglected tropical diseases2012

Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis.

Tie-Wu Jia, Sara Melville, Jürg Utzinger, Charles H King, Xiao-Nong Zhou

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 7 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 7 syntheses or guidelines pooled it, 435 citations in OpenAlex.

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194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Tie-Wu JiaKey Laboratory on Biology of Parasites and Vectors, MOH, WHO Collaborating Center on Malaria, Schistosomiasis and Filariasis, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People's Republic of China. jiatiewu@sina.com
Sara Melville
Jürg Utzinger
Charles H King
Xiao-Nong Zhou
Case Western Reserve University · USChinese Center For Disease Control and Prevention · CNNational Institute for Parasitic Diseases · CNSwiss Tropical and Public Health Institute · CHUniversity of Cambridge · GB

Funding

Eco-epidemiology of Schistosomiasis, Malaria and Polyparasitism in Coastal KenyaR01TW008067 · FIC · CASE WESTERN RESERVE UNIVERSITY · PI KING, CHARLES HARDING, KITRON, URIEL DAN · 2007 to 2011
$2.4M
FIC NIH HHS R01 TW008067
6 · The paper itself

Abstract

backgroundSoil-transmitted helminth (STH) infections (i.e., Ascaris lumbricoides, hookworm, and Trichuris trichiura) affect more than a billion people. Preventive chemotherapy (i.e., repeated administration of anthelmintic drugs to at-risk populations), is the mainstay of control. This strategy, however, does not prevent reinfection. We performed a systematic review and meta-analysis to assess patterns and dynamics of STH reinfection after drug treatment. METHODOLOGY: We systematically searched PubMed, ISI Web of Science, EMBASE, Cochrane Database of Systematic Reviews, China National Knowledge Infrastructure, WanFang Database, Chinese Scientific Journal Database, and Google Scholar. Information on study year, country, sample size, age of participants, diagnostic method, drug administration strategy, prevalence and intensity of infection pre- and posttreatment, cure and egg reduction rate, evaluation period posttreatment, and adherence was extracted. Pooled risk ratios from random-effects models were used to assess the risk of STH reinfection after treatment. Our protocol is available on PROSPERO, registration number: CRD42011001678. PRINCIPAL

findingsFrom 154 studies identified, 51 were included and 24 provided STH infection rates pre- and posttreatment, whereas 42 reported determinants of predisposition to reinfection. At 3, 6, and 12 months posttreatment, A. lumbricoides prevalence reached 26% (95% confidence interval (CI): 16-43%), 68% (95% CI: 60-76%) and 94% (95% CI: 88-100%) of pretreatment levels, respectively. For T. trichiura, respective reinfection prevalence were 36% (95% CI: 28-47%), 67% (95% CI: 42-100%), and 82% (95% CI: 62-100%), and for hookworm, 30% (95% CI: 26-34%), 55% (95% CI: 34-87%), and 57% (95% CI: 49-67%). Prevalence and intensity of reinfection were positively correlated with pretreatment infection status.

conclusionSTH reinfections occur rapidly after treatment, particularly for A. lumbricoides and T. trichiura. Hence, there is a need for frequent anthelmintic drug administrations to maximize the benefit of preventive chemotherapy. Integrated control approaches emphasizing health education and environmental sanitation are needed to interrupt transmission of STH.

Indexed as

AnimalsAnthelminticsAscariasisDrug TherapyHelminthiasisHookworm InfectionsHumansRecurrenceTrichuriasisAnthelmintics

Identifiers

PMID22590656
PMCPMC3348161
OpenAlexW2086511108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.