Trial reportPloS one2012
Implementation of anaphylaxis management guidelines: a register-based study.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 68 citations in OpenAlex.
- Epidemiology, Risk Factors, and Management of Biphasic Anaphylaxis.Current allergy and asthma reports · 2024Review
- Natural History and Risk Factors of Hymenoptera Venom Allergy in Dogs.Animals : an open access journal from MDPI · 2024Article
- Quality of Life in the Management of Anaphylaxis in Food-Allergic Adults.International journal of general medicine · 2024Article
- Measuring the Impact of Food Immunotherapy on Health-Related Quality of Life in Clinical Trials.Frontiers in allergy · 2022Review
- Preparedness of pre-intern medical graduates of three universities in Sri Lanka to diagnose and manage anaphylaxis.BMC medical education · 2021Article
- Psychosocial Mediators of Change and Patient Selection Factors in Oral Immunotherapy Trials.Clinical reviews in allergy & immunology · 2018Review
- Important and specific role for basophils in acute allergic reactions.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Review
- A national survey of Russian physicians' knowledge of diagnosis and management of food-induced anaphylaxis.BMJ open · 2017Article
- Drug-induced anaphylaxis in the emergency room.Acute medicine & surgery · 2017Review
- Acute and preventive management of anaphylaxis in German primary school and kindergarten children.BMC pediatrics · 2015Article
- Level of knowledge about anaphylaxis and its management among health care providers.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Article
- Triggers and treatment of anaphylaxis: an analysis of 4,000 cases from Germany, Austria and Switzerland.Deutsches Arzteblatt international · 2014Article
- International consensus on (ICON) anaphylaxis.The World Allergy Organization journal · 2014Article
- Evaluating the management of anaphylaxis in US emergency departments: Guidelines vs. practice.World journal of emergency medicine · 2013Article
- Quality of life in the setting of anaphylaxis and food allergy.Allergo journal internationalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaphylaxis management guidelines recommend the use of intramuscular adrenaline in severe reactions, complemented by antihistamines and corticoids; secondary prevention includes allergen avoidance and provision of self-applicable first aid drugs. Gaps between recommendations and their implementation have been reported, but only in confined settings. Hence, we analysed nation-wide data on the management of anaphylaxis, evaluating the implementation of guidelines.
methodsWithin the anaphylaxis registry, allergy referral centres across Germany, Austria and Switzerland provided data on severe anaphylaxis cases. Based on patient records, details on reaction circumstances, diagnostic workup and treatment were collected via online questionnaire. Report of anaphylaxis through emergency physicians allowed for validation of registry data.
results2114 severe anaphylaxis patients from 58 centres were included. 8% received adrenaline intravenously, 4% intramuscularly; 50% antihistamines, and 51% corticoids. Validation data indicated moderate underreporting of first aid drugs in the Registry. 20% received specific instructions at the time of the reaction; 81% were provided with prophylactic first aid drugs at any time.
conclusionThere is a distinct discrepancy between current anaphylaxis management guidelines and their implementation. To improve patient care, a revised approach for medical education and training on the management of severe anaphylaxis is warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.