ArticleDementia and geriatric cognitive disorders extra2012
Exercise and early-onset Alzheimer's disease: theoretical considerations.
Article in Dementia and geriatric cognitive disorders extra, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of Physical Activity in Nursing Home Residents with Dementia: A Randomized Controlled Trial.Dementia and geriatric cognitive disorders · 2018Trial
- Physical activity program for patients with dementia and their relative caregivers: randomized clinical trial in Primary Health Care (AFISDEMyF study).BMC neurology · 2014Trial
- Study protocol: EXERcise and cognition in sedentary adults with early-ONset dementia (EXERCISE-ON).BMC neurology · 2012Trial
- Exercise therapy to prevent and treat Alzheimer's disease.Frontiers in aging neuroscience · 2023Review
- Relationship between Associated Neuropsychological Factors and Fall Risk Factors in Community-Dwelling Elderly.Healthcare (Basel, Switzerland) · 2022Article
- The occurrence of cerebrovascular atherosclerosis in Alzheimer's disease patients.Clinical interventions in aging · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsAlthough studies show a negative relationship between physical activity and the risk for cognitive impairment and late-onset Alzheimer's disease, studies concerning early-onset Alzheimer's disease (EOAD) are lacking. This review aims to justify the value of exercise interventions in EOAD by providing theoretical considerations that include neurobiological processes.
methodsA literature search on key words related to early-onset dementia, exercise, imaging, neurobiological mechanisms, and cognitive reserve was performed. RESULTS/
conclusionBrain regions and neurobiological processes contributing to the positive effects of exercise are affected in EOAD and, thus, provide theoretical support for exercise interventions in EOAD. Finally, we present the design of a randomized controlled trial currently being conducted in early-onset dementia patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.