SynthesisPLoS genetics2012
Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
Synthesis in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.Nature genetics · 2017Pooled it
- Pooled it
- A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).PloS one · 2015Pooled it
- Estrogen Deficiency and the Origin of Obesity during Menopause.BioMed research international · 2014Pooled it
- Human Genetics of Adipose Dysfunction: Genomic Mechanisms and Therapeutic Opportunities in Cardiometabolic Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Genome-Wide Association Study of Pericardial Fat Area in 28 161 UK Biobank Participants.Journal of the American Heart Association · 2023Article
- Sex Differences in Adiposity and Cardiovascular Diseases.International journal of molecular sciences · 2022Review
- Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.Human molecular genetics · 2021Article
- Review
- Heritability of fat distributions in male mice from the founder strains of the Diversity Outbred mouse population.G3 (Bethesda, Md.) · 2021Article
- Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker.Clinical Medicine Insights. Cardiology · 2021Article
- Genomics of body fat distribution.Journal of genetics · 2021Review
- Article
- Developmentally Driven Changes in Adipogenesis in Different Fat Depots Are Related to Obesity.Frontiers in endocrinology · 2020Article
- Gene-Environment Interactions on Body Fat Distribution.International journal of molecular sciences · 2019Review
- Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.Molecular metabolism · 2018Article
- Transcription factor 21 (TCF21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells.The Journal of biological chemistry · 2018Article
- Associations of adult genetic risk scores for adiposity with childhood abdominal, liver and pericardial fat assessed by magnetic resonance imaging.International journal of obesity (2005) · 2018Article
- Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.Nature communications · 2017Article
- P4 medicine approach to obstructive sleep apnoea.Respirology (Carlton, Vic.) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 11 institutions in 2 countries.
Funding
Abstract
Pericardial fat is a localized fat depot associated with coronary artery calcium and myocardial infarction. We hypothesized that genetic loci would be associated with pericardial fat independent of other body fat depots. Pericardial fat was quantified in 5,487 individuals of European ancestry from the Framingham Heart Study (FHS) and the Multi-Ethnic Study of Atherosclerosis (MESA). Genotyping was performed using standard arrays and imputed to ~2.5 million Hapmap SNPs. Each study performed a genome-wide association analysis of pericardial fat adjusted for age, sex, weight, and height. A weighted z-score meta-analysis was conducted, and validation was obtained in an additional 3,602 multi-ethnic individuals from the MESA study. We identified a genome-wide significant signal in our primary meta-analysis at rs10198628 near TRIB2 (MAF 0.49, p = 2.7 × 10(-08)). This SNP was not associated with visceral fat (p = 0.17) or body mass index (p = 0.38), although we observed direction-consistent, nominal significance with visceral fat adjusted for BMI (p = 0.01) in the Framingham Heart Study. Our findings were robust among African ancestry (n = 1,442, p = 0.001), Hispanic (n = 1,399, p = 0.004), and Chinese (n = 761, p = 0.007) participants from the MESA study, with a combined p-value of 5.4E-14. We observed TRIB2 gene expression in the pericardial fat of mice. rs10198628 near TRIB2 is associated with pericardial fat but not measures of generalized or visceral adiposity, reinforcing the concept that there are unique genetic underpinnings to ectopic fat distribution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.