ArticlePLoS genetics2012
Extent, causes, and consequences of small RNA expression variation in human adipose tissue.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Caloric restriction modifies small RNA profiles and engages age-related molecular pathways in the CALERIE trial.iScience · 2026Article
- CorrAdjust unveils biologically relevant transcriptomic correlations by efficiently eliminating hidden confounders.Nucleic acids research · 2025Article
- Genetic architecture of microRNA expression and its link to complex diseases in the Japanese population.Human molecular genetics · 2022Article
- A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Article
- Aberrant Expressional Profiling of Small RNA by Cold Atmospheric Plasma Treatment in Human Chronic Myeloid Leukemia Cells.Frontiers in genetics · 2021Article
- Population variation in miRNAs and isomiRs and their impact on human immunity to infection.Genome biology · 2020Article
- MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.EBioMedicine · 2019Article
- MiR-323b-5p acts as a novel diagnostic biomarker for critical limb ischemia in type 2 diabetic patients.Scientific reports · 2018Article
- Heritable components of the human fecal microbiome are associated with visceral fat.Gut microbes · 2018Article
- Principles and methods of in-silico prioritization of non-coding regulatory variants.Human genetics · 2018Review
- Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits.Open biology · 2017Article
- A Smoking-Associated miRNA-mRNA Coexpression Network.Circulation. Cardiovascular genetics · 2017Article
- Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci.Genetics · 2016Article
- miR-200a regulates Rheb-mediated amelioration of insulin resistance after duodenal-jejunal bypass.International journal of obesity (2005) · 2016Article
- The role of regulatory variation in complex traits and disease.Nature reviews. Genetics · 2015Review
- Article
- Personalized medicine: from genotypes, molecular phenotypes and the quantified self, towards improved medicine.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2015Article
- Obesity Associated Modulation of miRNA and Co-Regulated Target Transcripts in Human Adipose Tissue of Non-Diabetic Subjects.MicroRNA (Shariqah, United Arab Emirates) · 2015Article
- Genetics of gene expression in immunity to infection.Current opinion in immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 9 institutions in 5 countries.
Funding
Abstract
Small RNAs are functional molecules that modulate mRNA transcripts and have been implicated in the aetiology of several common diseases. However, little is known about the extent of their variability within the human population. Here, we characterise the extent, causes, and effects of naturally occurring variation in expression and sequence of small RNAs from adipose tissue in relation to genotype, gene expression, and metabolic traits in the MuTHER reference cohort. We profiled the expression of 15 to 30 base pair RNA molecules in subcutaneous adipose tissue from 131 individuals using high-throughput sequencing, and quantified levels of 591 microRNAs and small nucleolar RNAs. We identified three genetic variants and three RNA editing events. Highly expressed small RNAs are more conserved within mammals than average, as are those with highly variable expression. We identified 14 genetic loci significantly associated with nearby small RNA expression levels, seven of which also regulate an mRNA transcript level in the same region. In addition, these loci are enriched for variants significant in genome-wide association studies for body mass index. Contrary to expectation, we found no evidence for negative correlation between expression level of a microRNA and its target mRNAs. Trunk fat mass, body mass index, and fasting insulin were associated with more than twenty small RNA expression levels each, while fasting glucose had no significant associations. This study highlights the similar genetic complexity and shared genetic control of small RNA and mRNA transcripts, and gives a quantitative picture of small RNA expression variation in the human population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.