ArticleThe Malaysian journal of medical sciences : MJMS2011
Effects of duration of diabetes on behavioural and cognitive parameters in streptozotocin-induced juvenile diabetic rats.
Article in The Malaysian journal of medical sciences : MJMS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Neutral Protamine Hagedorn (NPH) insulin attenuates memory impairments in diabetic rats.Diabetology & metabolic syndrome · 2025Article
- Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis.Pharmacological reports : PR · 2023Review
- Behavioral and Proteomic Studies Reveal Methylglyoxal Activate Pathways Associated with Alzheimer's Disease.ACS pharmacology & translational science · 2023Article
- Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Article
- Beneficial Effect of Leptin on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats.Balkan medical journal · 2016Article
- Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma.EBioMedicine · 2016Article
- Anti-inflammatory Effect of Astaxanthin on the Sickness Behavior Induced by Diabetes Mellitus.Cellular and molecular neurobiology · 2015Article
- Effects of chlorogenic acid, caffeine, and coffee on behavioral and biochemical parameters of diabetic rats.Molecular and cellular biochemistry · 2014Article
- Crocin improved learning and memory impairments in streptozotocin-induced diabetic rats.Iranian journal of basic medical sciences · 2013Article
- Diabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins.Basic and clinical neuroscienceArticle
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Authors and funding
3 authors.
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Abstract
backgroundDiabetic encephalopathy is a recently recognised complication of early-onset type 1 diabetes in children. The abnormalities underlying diabetic encephalopathy are complex and poorly understood, and the impact of disease duration on behavioural and cognitive parameters also remains unclear. Hence, the present study was conducted to determine the effects of different durations of hyperglycaemia on behavioural and cognitive parameters in young streptozotocin-induced diabetic rats.
methodsDiabetes was induced in young, weaned, age-matched rat pups by streptozotocin injection (50 mg/kg body weight, intraperitoneally). Diabetic status was confirmed on post-natal day 30. The rats were tested in the elevated plus maze 10 and 2o days after diabetes induction.
resultsDiabetic rats had significantly impaired behavioural and cognitive functions compared with age-matched controls. Increased anxiety levels and cognitive deficits were observed in rats that had been diabetic for 20 days compared with their 10-day counterparts.
conclusionIt is essential to diagnose and treat early-onset type 1 diabetes in young children to prevent irreversible cognitive dysfunction.
Indexed as
Identifiers
22589670PMC3328933What OpenQuestion holds
Registered trials
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