Trial reportEnvironmental health perspectives2012
Ambient temperature and biomarkers of heart failure: a repeated measures analysis.
Trial report in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ambient Temperature and Cardiac Biomarkers: A Meta-Analysis.Current cardiology reviews · 2023Pooled it
- Higher Daily Air Temperature Is Associated with Shorter Leukocyte Telomere Length: KORA F3 and KORA F4.Environmental science & technology · 2022Pooled it
- Ambient temperature and the variability between neighbouring days impacts in-patient hospitalizations in the United Kingdom.Communications medicine · 2026Article
- Evaluation of the relationship between Air Health Index and the risk of cardiovascular and cerebrovascular disease mortality in Huizhou City: a cross-sectional study.BMJ public health · 2026Article
- Mortality Risk from Chronic Ischemic Heart Disease Associated with Short-Term Co-Exposure to Summer Heatwave and Ozone.Journal of urban health : bulletin of the New York Academy of Medicine · 2025Article
- Impact of extreme temperature on congenital heart disease mortality: a population-based nationwide case-crossover study.The Lancet regional health. Western Pacific · 2024Article
- Sex-Specific Association of Ambient Temperature With Urine Biomarkers in Southwest Coastal Bangladesh.Kidney international reports · 2024Article
- Self-Reported Outdoor Light Exposure Time and Incident Heart Failure.Journal of the American Heart Association · 2024Article
- An Improved Air Health Index Based on Short-Term Cardiovascular Effects in Tianjin, China.International journal of public health · 2024Article
- Effect of Temperature on Emergency Ambulance Call-Outs for Cardiovascular Causes: A Scoping Review.Environment & health (Washington, D.C.) · 2023Article
- Association Between the Incidence of Hospitalizations for Acute Cardiovascular Events, Weather, and Air Pollution.JACC. Advances · 2023Article
- Relationship between birth weight and ambient temperature during pregnancy in a cross-sectional study of the residents of Suzhou, China.Frontiers in public health · 2023Article
- Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age.Environment international · 2022Article
- Social and environmental risks as contributors to the clinical course of heart failure.Heart failure reviews · 2022Review
- Association between ambient temperature and daily emergency hospitalizations for acute coronary syndrome in Yancheng, China.Environmental science and pollution research international · 2020Article
- Short-term effects of ambient air pollution and outdoor temperature on biomarkers of myocardial damage, inflammation and oxidative stress in healthy adults.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Vulnerability to the Cardiovascular Effects of Ambient Heat in Six US Cities: Results from the Multi-Ethnic Study of Atherosclerosis (MESA).Epidemiology (Cambridge, Mass.) · 2018Article
- Short-Term Effects of Heat on Mortality and Effect Modification by Air Pollution in 25 Italian Cities.International journal of environmental research and public health · 2018Article
- Climate change, heat, and mortality in the tropical urban area of San Juan, Puerto Rico.International journal of biometeorology · 2018Article
- Acute Associations Between Outdoor Temperature and Premature Rupture of Membranes.Epidemiology (Cambridge, Mass.) · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundExtreme temperatures have been associated with hospitalization and death among individuals with heart failure, but few studies have explored the underlying mechanisms.
objectivesWe hypothesized that outdoor temperature in the Boston, Massachusetts, area (1- to 4-day moving averages) would be associated with higher levels of biomarkers of inflammation and myocyte injury in a repeated-measures study of individuals with stable heart failure.
methodsWe analyzed data from a completed clinical trial that randomized 100 patients to 12 weeks of tai chi classes or to time-matched education control. B-type natriuretic peptide (BNP), C-reactive protein (CRP), and tumor necrosis factor (TNF) were measured at baseline, 6 weeks, and 12 weeks. Endothelin-1 was measured at baseline and 12 weeks. We used fixed effects models to evaluate associations with measures of temperature that were adjusted for time-varying covariates.
resultsHigher apparent temperature was associated with higher levels of BNP beginning with 2-day moving averages and reached statistical significance for 3- and 4-day moving averages. CRP results followed a similar pattern but were delayed by 1 day. A 5°C change in 3- and 4-day moving averages of apparent temperature was associated with 11.3% [95% confidence interval (CI): 1.1, 22.5; p = 0.03) and 11.4% (95% CI: 1.2, 22.5; p = 0.03) higher BNP. A 5°C change in the 4-day moving average of apparent temperature was associated with 21.6% (95% CI: 2.5, 44.2; p = 0.03) higher CRP. No clear associations with TNF or endothelin-1 were observed.
conclusionsAmong patients undergoing treatment for heart failure, we observed positive associations between temperature and both BNP and CRP-predictors of heart failure prognosis and severity.
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