ReviewPediatric nephrology (Berlin, Germany)2013
Urine biomarkers in juvenile-onset SLE nephritis.
Review in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Does kidney biopsy in pediatric lupus patients "complement" the management and outcomes of silent lupus nephritis? Lessons learned from a pediatric cohort.Pediatric nephrology (Berlin, Germany) · 2023Observational
- Evaluation of red blood cell distribution width-platelet ratio as a predictor of adverse pregnancy outcomes and disease severity in systemic lupus erythematosus.Clinical rheumatology · 2022Article
- Article
- High-Throughput Sequencing-Based Analysis of T Cell Repertoire in Lupus Nephritis.Frontiers in immunology · 2020Article
- Class IV Lupus Nephritis in the Setting of Serologically Quiescent Disease and Normal Urine Sediment in a Patient with Late-Onset Systemic Lupus Erythematosus.Case reports in rheumatology · 2019Article
- Podocytes contribute, and respond, to the inflammatory environment in lupus nephritis.American journal of physiology. Renal physiology · 2018Article
- Urinary Albumin Levels are Independently Associated with Renal Lesion Severity in Patients with Lupus Nephritis and Little or No Proteinuria.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Treatable renal disease in children with silent lupus nephritis detected by baseline biopsy: association with serum C3 levels.Clinical rheumatology · 2017Article
- Towards new avenues in the management of lupus glomerulonephritis.Nature reviews. Rheumatology · 2016Review
- Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis.Experimental & molecular medicine · 2016Article
- High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus.American journal of nephrology · 2015Article
- The pathogenesis, diagnosis and treatment of lupus nephritis.Current opinion in rheumatology · 2014Review
- Mean platelet volume as an indicator of disease activity in juvenile SLE.Clinical rheumatology · 2014Article
- Urine biomarkers for monitoring juvenile lupus nephritis: a prospective longitudinal study.Pediatric nephrology (Berlin, Germany) · 2014Article
- Biomarkers in systemic lupus erythematosus: challenges and prospects for the future.Therapeutic advances in musculoskeletal disease · 2013Article
- Use of biomarkers in the management of children with lupus.Current rheumatology reports · 2013Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over 80 % of patients with juvenile-onset systemic lupus erythematosus will have renal involvement compared to 40 % with adult-onset disease. Up to 44 % of children who do have lupus nephritis (LN) progress to renal failure in early adulthood. Improved methods of detecting onset of LN would allow earlier treatment, which may prevent irreversible renal scarring and a decline in renal function. Current conventional markers of disease activity fail to adequately predict renal lupus flares and include proteinuria, complement levels, anti-double-stranded DNA antibodies and serum creatinine concentrations. Standardized histological classification is currently the gold standard for diagnosing and classifying LN, but its invasive nature limits routine use for monitoring, especially in a childhood population. Novel biomarkers need to be sensitive and specific-and preferably non-invasive and cost-effective. The most promising biomarkers in juvenile-onset LN include urinary neutrophil gelatinase associated lipocalin, monocyte chemoattractant protein 1 and transforming growth factor-beta, although many others have been identified and are under investigation. No one biomarker yet discovered is unique to LN, indicating an overlap in disease pathophysiology. It is likely that a combination of biomarkers will be required for assessing disease flare detection, response to treatment and prognostic information. Potential biomarkers require longitudinal validation in large paediatric, prospective cohorts to assess their ability to act as clinically useful adjuncts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.