Trial reportJournal of thrombosis and thrombolysis2012
Mean platelet volume and D-dimer in patients with suspected deep venous thrombosis.
Trial report in Journal of thrombosis and thrombolysis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Incidence and risk factors of PICC-related thrombosis in breast cancer: a meta-analysis.Japanese journal of clinical oncology · 2024Pooled it
- Diagnosis of deep vein thrombosis of the lower extremity: a systematic review and meta-analysis of test accuracy.Blood advances · 2020Pooled it
- American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism.Blood advances · 2018Guideline
- Proteomic Analysis of the Antidepressant Effects of Shen-Zhi-Ling in Depressed Patients: Identification of Proteins Associated with Platelet Activation and Lipid Metabolism.Cellular and molecular neurobiology · 2018Trial
- Serum lncRNA RAMP2-AS1 Served as a Biomarker of Deep Vein Thrombosis Occurrence and Development in Elderly.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024Article
- Predictive factors on postoperative venous thromboembolism after minimally invasive colorectal cancer surgery: a retrospective observational study.BMC surgery · 2023Observational
- Frequency of deep vein thrombosis at admission for acute stroke and associated factors: a cross-sectional study.Thrombosis journal · 2021Article
- Utility of platelet-to-lymphocyte ratio to support the diagnosis of acute deep vein thrombosis.Turk gogus kalp damar cerrahisi dergisi · 2019Article
- A new diagnostic marker for acute pulmonary embolism in emergency department: mean platelet volume.African health sciences · 2014Article
- The diagnostic value of MPV and D-dimer for acute DVT.Journal of thrombosis and thrombolysis · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this retrospective study was to evaluate the diagnostic value of mean platelet volume (MPV) and D-dimer for acute deep venous thromboembolism (DVT). Two hundred and fifty six patients who presented to the emergency or cardiovascular surgery department with suspected lower limb DVT were retrospectively recruited. Plasma levels of MPV, platelet count, and D-dimer were obtained and duplex sonography examination was performed for all patients. Eighty four patients had acute DVT which was diagnosed by duplex ultrasonography. MPV was significantly higher in patients with DVT than in those without DVT (p < 0.01). The mean MPV was 7.97 ± 17.8 and 7.58 ± 0.87 fL in patients with DVT and without DVT, respectively (p < 0.01). D-dimer was significantly higher in patients with DVT (p < 0.01). For all the patients, a positive MPV when the cut-off value was 7.3 fL, had 69.7 % sensitivity and 43.9 % specificity. D-dimer (with a cut-off value of 0.5 μg/mL) had 82.9 % sensitivity and 32.7 % specificity. In case of combination of MPV and D-dimer, the specificity exceeded (65.9 %) despite the reduction in sensitivity (59.2 %). Elevated MPV was found to be associated with acute DVT and high levels of MPV might increase the specificity of D-dimer for exclusion of DVT.
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