ReviewEuropean biophysics journal : EBJ2012
Model-based approaches for the determination of lipid bilayer structure from small-angle neutron and X-ray scattering data.
Review in European biophysics journal : EBJ, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- SuAVE-Scatter: A Module for Integrating Simulations and SAXS/SANS Analyses.Journal of chemical information and modeling · 2026Article
- Development of Transferable Coarse-Grained Lipid Models with Optimized Structural and Elastic Membrane Properties.Journal of chemical theory and computation · 2025Article
- Modification of Liposomal Properties by an Engineered Gemini Surfactant.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Neutron spin echo shows pHLIP is capable of retarding membrane thickness fluctuations.Biochimica et biophysica acta. Biomembranes · 2024Article
- Cryo-EM images of phase-separated lipid bilayer vesicles analyzed with a machine-learning approach.Biophysical journal · 2024Article
- Arginine-Rich Cell-Penetrating Peptides Induce Lipid Rearrangements for Their Active Translocation across Laterally Heterogeneous Membranes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Efficient calculation of orientation-dependent lipid dynamics from membrane simulations.bioRxiv : the preprint server for biology · 2024Article
- Quantitative Comparison against Experiments Reveals Imperfections in Force Fields' Descriptions of POPC-Cholesterol Interactions.Journal of chemical theory and computation · 2023Article
- Visualizing lipid membrane structure with cryo-EM: past, present, and future.Emerging topics in life sciences · 2023Review
- Pathways of Membrane Solubilization: A Structural Study of Model Lipid Vesicles Exposed to Classical Detergents.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Absorption of the [bmim][Cl] Ionic Liquid in DMPC Lipid Bilayers across Their Gel, Ripple, and Fluid Phases.The journal of physical chemistry. B · 2022Article
- Vesicle Viewer: Online visualization and analysis of small-angle scattering from lipid vesicles.Biophysical journal · 2021Article
- The effect of polydispersity, shape fluctuations and curvature on small unilamellar vesicle small-angle X-ray scattering curves.Journal of applied crystallography · 2021Article
- Implementation of a self-consistent slab model of bilayer structure in theJournal of applied crystallography · 2021Article
- Biomembrane Structure and Material Properties Studied With Neutron Scattering.Frontiers in chemistry · 2021Review
- Small AgNP in the Biopolymer Nanocomposite System.International journal of molecular sciences · 2020Article
- Refining internal bilayer structure of bicelles resolved by extended-q small angle X-ray scattering.Chemistry and physics of lipids · 2020Article
- Direct label-free imaging of nanodomains in biomimetic and biological membranes by cryogenic electron microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Molecular Structure of Sphingomyelin in Fluid Phase Bilayers Determined by the Joint Analysis of Small-Angle Neutron and X-ray Scattering Data.The journal of physical chemistry. B · 2020Article
- On the Mechanism of Bilayer Separation by Extrusion, or Why Your LUVs Are Not Really Unilamellar.Biophysical journal · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Some of our recent work has resulted in the detailed structures of fully hydrated, fluid phase phosphatidylcholine (PC) and phosphatidylglycerol (PG) bilayers. These structures were obtained from the joint refinement of small-angle neutron and X-ray data using the scattering density profile (SDP) models developed by Kučerka et al. (Biophys J 95:2356-2367, 2008; J Phys Chem B 116:232-239, 2012). In this review, we first discuss models for the standalone analysis of neutron or X-ray scattering data from bilayers, and assess the strengths and weaknesses inherent to these models. In particular, it is recognized that standalone data do not contain enough information to fully resolve the structure of naturally disordered fluid bilayers, and therefore may not provide a robust determination of bilayer structure parameters, including the much-sought-after area per lipid. We then discuss the development of matter density-based models (including the SDP model) that allow for the joint refinement of different contrast neutron and X-ray data, as well as the implementation of local volume conservation within the unit cell (i.e., ideal packing). Such models provide natural definitions of bilayer thicknesses (most importantly the hydrophobic and Luzzati thicknesses) in terms of Gibbs dividing surfaces, and thus allow for the robust determination of lipid areas through equivalent slab relationships between bilayer thickness and lipid volume. In the final section of this review, we discuss some of the significant findings/features pertaining to structures of PC and PG bilayers as determined from SDP model analyses.
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