ArticleJournal of neuropathology and experimental neurology2012
Altered pharyngeal muscles in Parkinson disease.
Article in Journal of neuropathology and experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Respiratory-Swallow Coordination in Individuals with Parkinson's Disease: A Systematic Review and Meta-Analysis.Journal of Parkinson's disease · 2023Pooled it
- A comprehensive review of the diagnosis and treatment of Parkinson's disease dysphagia and aspiration.Expert review of gastroenterology & hepatology · 2020Pooled it
- Pooled it
- Kinematic Features of Laryngeal Motor Control in Parkinson's Disease.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Respiratory-swallowing Measures and the Impact of Bolus Hold in Individuals with Parkinson's Disease.Dysphagia · 2026Article
- LaminA/C-dependent cellular senescence signaling promotes skeletal muscle atrophy and abnormalities in Parkinson's disease.Cell death & disease · 2026Article
- Is Dysphagia in Multiple System Atrophy Responsive to Levodopa? Results from a Retrospective Study.Movement disorders clinical practice · 2026Article
- Alpha-Synuclein Lesions in the Peripheral Nervous System of the Larynx in Parkinson's Disease.Dysphagia · 2026Article
- Respiratory-Swallowing Phase Pattern and Swallowing Impairment in Individuals With Parkinson's Disease.Journal of speech, language, and hearing research : JSLHR · 2026Article
- An Unusual Case of a Hypopharyngeal Mass in a Patient Presenting With Weakness.Case reports in otolaryngology · 2026Article
- Dysphagia and oropharyngeal bradykinesia in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Classifying neurogenic dysphagia as a movement disorder.Brain : a journal of neurology · 2025Review
- Association between Perceived Dysphagia Symptoms and Swallowing Physiology in Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Alpha-synuclein overexpression does not cause vocalization deficits in a mouse model of parkinsonism.Biology open · 2025Article
- Neurogenic Dysphagia: Peripheral and Central Neuromodulation.Clinics and practice · 2025Review
- Pan-Gut Dysmotility in Parkinson Disease.Gastroenterology & hepatology · 2025Article
- The fixel GI Parkinson's research and integrated support model (PRISM).Journal of Parkinson's disease · 2025Article
- Review
- LRRK2Journal of cachexia, sarcopenia and muscle · 2024Article
- Effects of Age and Parkinson's Disease on the Relationship between Vocal Fold Abductory Kinematics and Relative Fundamental Frequency.Journal of voice : official journal of the Voice Foundation · 2024Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Dysphagia (impaired swallowing) is common in patients with Parkinson disease (PD) and is related to aspiration pneumonia, the primary cause of death in PD. Therapies that ameliorate the limb motor symptoms of PD are ineffective for dysphagia. This suggests that the pathophysiology of PD dysphagia may differ from that affecting limb muscles, but little is known about potential neuromuscular abnormalities in the swallowing muscles in PD. This study examined the fiber histochemistry of pharyngeal constrictor and cricopharyngeal sphincter muscles in postmortem specimens from 8 subjects with PD and 4 age-matched control subjects. Pharyngeal muscles in subjects with PD exhibited many atrophic fibers, fiber type grouping, and fast-to-slow myosin heavy chain transformation. These alterations indicate that the pharyngeal muscles experienced neural degeneration and regeneration over the course of PD. Notably, subjects with PD with dysphagia had a higher percentage of atrophic myofibers versus with those without dysphagia and controls. The fast-to-slow fiber-type transition is consistent with abnormalities in swallowing, slow movement of food, and increased tone in the cricopharyngeal sphincter in subjects with PD. The alterations in the pharyngeal muscles may play a pathogenic role in the development of dysphagia in subjects with PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.