SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Inflammatory markers and bariatric surgery: a meta-analysis.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 6 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- The Effect of Bariatric Surgery on Circulating Levels of Lipoprotein (a): A Meta-analysis.BioMed research international · 2022Pooled it
- The influence of bariatric surgery on oral drug bioavailability in patients with obesity: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Pooled it
- Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis.Obesity surgery · 2019Pooled it
- Effects of bariatric surgery on markers of subclinical atherosclerosis and endothelial function: a meta-analysis of literature studies.International journal of obesity (2005) · 2016Pooled it
- Effects of bariatric surgery on incidence of obesity-related cancers: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- The effects of bariatric surgery on colorectal cancer risk: systematic review and meta-analysis.Obesity surgery · 2014Pooled it
- Trial
- Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity.British journal of clinical pharmacology · 2022Trial
- Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases.Obesity surgery · 2018Trial
- Attenuated improvements in adiponectin and fat loss characterize type 2 diabetes non-remission status after bariatric surgery.Diabetes, obesity & metabolism · 2014Trial
- Preoperative Serum Transient Receptor Potential Ankyrin 1 (TRPA1) Levels in Class III Obesity: A Prospective Controlled Observational Study.International journal of molecular sciences · 2026Observational
- Short-Term Changes in Salivary IL-6, TNF-α, and Periodontal Inflammation Following Sleeve Gastrectomy in Patients with Obesity: A Randomized Controlled Pilot Study.Biomedicines · 2026Article
- Impact of Gastric Histopathology on Weight Loss and Metabolic Outcomes Following Laparoscopic Sleeve Gastrectomy: A Retrospective Cohort Study.Obesity surgery · 2026Article
- Anti-Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea.Chronic diseases and translational medicine · 2026Review
- Article
- Microbial Shifts After Sleeve Gastrectomy: The Gut-Oral Axis, Periodontal Outcomes, and Competing Oral Risks.Biomedicines · 2026Review
- A Contemporary Perspective on Long-Term Complications of Bariatric Surgery.Obesity surgery · 2026Review
- Assessing the impact of bariatric surgery on cardiovascular risk in type 2 diabetes: a systematic review and meta-analysis using OMICs data.Diabetology & metabolic syndrome · 2025Review
- Anthropometric Changes and Systemic Inflammation After Sleeve Gastrectomy: Do Composite Markers Reflect the Change?Obesity surgery · 2025Article
- Characterizing the effect of bariatric surgery on circulating S100A9.International journal of obesity (2005) · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveObesity is a state of chronic low grade inflammation with increased levels of inflammatory markers such as C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF) α. The changes of some of the above markers after bariatric surgery are not consistent across studies. The objective of this study is to confirm the changes in blood levels of CRP, IL-6 and TNFα after bariatric surgery.
methodsA Pubmed and EMBASE search was performed for studies measuring the above cytokines in blood before and after bariatric surgery. A meta-analysis was performed for the changes in CRP, TNFα and IL-6 for the maximum follow-up time in each study as well as for discrete follow-up times.
resultsOnly observational studies could be retrieved. Bariatric surgery produces about 66 and 27 % reduction in CRP and IL-6 levels, respectively. The change in TNFα after bariatric surgery did not approach statistical significance.
conclusionBariatric surgery decreases the low grade inflammation associated with obesity as measured by CRP and IL-6 levels. The change of TNFα after bariatric surgery should be further investigated with randomized trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.