ArticlePsychopharmacology2012
The effect of morphine dependence on impulsive choice in rats.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Contributions of the interaction between mu-opioid receptors and dopamine receptors in the regulation of risky decision making.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behaviour.Addiction biology · 2024Article
- Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments.Pharmacological reviews · 2023Review
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behavior.bioRxiv : the preprint server for biology · 2023Article
- Visual and Auditory Reaction Times of Patients with Opioid Use Disorder.Psychiatry investigation · 2019Article
- Adolescent morphine exposure induces immediate and long-term increases in impulsive behavior.Psychopharmacology · 2018Article
- Effects of morphine/CP55940 mixtures on an impulsive choice task in rhesus monkeys.Behavioural pharmacology · 2018Article
- Choice between delayed food and immediate oxycodone in rats.Psychopharmacology · 2016Article
- Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task.British journal of pharmacology · 2016Article
- Effect of daily morphine administration and its discontinuation on delay discounting of food in rhesus monkeys.Behavioural pharmacology · 2016Article
- Inflated reward value in early opiate withdrawal.Addiction biology · 2016Article
- The effect of acute morphine on delay discounting in dependent and non-dependent rats.Psychopharmacology · 2015Article
- Recent Translational Findings on Impulsivity in Relation to Drug Abuse.Current addiction reports · 2014Article
- Do the adjusting-delay and increasing-delay tasks measure the same construct: delay discounting?Behavioural pharmacology · 2014Article
- Delay discounting of oral morphine and sweetened juice rewards in dependent and non-dependent rats.Psychopharmacology · 2014Article
- Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Impulsivity and drugs of abuse: a juice-reinforced operant procedure for determining within-session delay discounting functions in rhesus monkeys.Journal of pharmacological and toxicological methodsArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleIn the human opiate-dependent population, the most consistently reported deficit in executive functioning is impulsivity. Previous research has shown that acute and chronic exposure to drugs of abuse can increase impulsive choice; however, the extent to which opiate dependence contributes to increased impulsivity has not been examined. We report here the effects of morphine dependence on rats' delay discounting (DD) of a sucrose reward.
methodsWe assigned rats randomly to either a dependent group that received a nightly 30 mg/kg subcutaneous dose of morphine or a morphine-naive group that received a nightly saline injection. DD of a sucrose reward was examined in rats prior to initiation of the dosing regimen, 22.5 h after the daily maintenance dose, and after a 14-day abstinence period.
resultsThe groups did not differ at baseline, but rats showed accelerated DD while dependent on morphine. After withdrawal from morphine, DD in previously dependent rats was not significantly different from that of naive rats. Since dependent rats also showed reduced motivation to acquire the sucrose reinforcer, we performed a separate experiment to test whether such a decrease in motivation could cause an increase in impulsivity. We found that food-deprived rats switched to a free-feeding diet did not differ in DD from rats maintained at 85 % of free-feeding weight.
conclusionsAn increase in impulsivity can result from physical dependence on morphine and cannot be attributed to changes in motivation to acquire sucrose-reinforced responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.