ArticleExperimental gerontology2012
Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products.
Article in Experimental gerontology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 84 citations in OpenAlex.
- Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial.The European respiratory journal · 2024Trial
- Inorganic Nitrite Supplementation Improves Endothelial Function With Aging: Translational Evidence for Suppression of Mitochondria-Derived Oxidative Stress.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Trial
- Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.The American journal of clinical nutrition · 2016Trial
- Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.Hypertension (Dallas, Tex. : 1979) · 2015Trial
- Nitrite supplementation alleviates cerebrovascular dysfunction in chronically stressed mice, but cognitive decline remains.Experimental physiology · 2026Article
- Associations Between the Severity of Obstructive Sleep Apnea and Arterial Stiffness Estimated by Pulse Wave Velocity Assessment: A Cross-Sectional Study.Health science reports · 2026Article
- Titin is a new factor regulating arterial stiffness through vascular smooth muscle cell tone in male rats.Physiological reports · 2025Article
- Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and Inflammatory Responses in Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- The Cardioprotective Role of Nitrate-Rich Vegetables.Foods (Basel, Switzerland) · 2024Review
- Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Nutraceuticals in the Prevention and Therapeutic Treatment of Cardiovascular and Cerebrovascular Disease.Journal of cardiopulmonary rehabilitation and prevention · 2023Review
- Promoting healthy cardiovascular aging: emerging topics.The journal of cardiovascular aging · 2022Article
- Carbamylation of elastic fibers is a molecular substratum of aortic stiffness.Scientific reports · 2021Article
- Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases.American journal of physiology. Heart and circulatory physiology · 2021Review
- Article
- Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice.The Journal of physiology · 2021Article
- Sex differences in the time course and mechanisms of vascular and cardiac aging in mice: role of the smooth muscle cell mineralocorticoid receptor.American journal of physiology. Heart and circulatory physiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We tested the hypothesis that sodium nitrite treatment reverses large elastic artery stiffening in old mice via reductions in collagen I, increases in elastin and/or decreases in advanced glycation end products (AGEs) mediated by reduced oxidative stress. Aortic pulse wave velocity (aPWV), a measure of large elastic artery stiffness, was greater in old (26-28months) compared with young (4-6months) control animals (520±9 vs. 405±6cm/s, p<0.05), and this was reversed by 3weeks of sodium nitrite treatment (50mg/L) (435±17cm/s). Age-related increases (p<0.05) in aortic superoxide production were associated with greater total and adventitial nitrotyrosine staining, all of which were reversed by nitrite treatment. Total and adventitial transforming growth factor β and collagen I were increased, and total and medial elastin were reduced with aging (p<0.05), but were unaffected by sodium nitrite. Aorta from old mice had increased total, adventitial and medial AGEs (p<0.05 vs. young), which were normalized by sodium nitrite treatment. In aortic segments from young mice in vitro, pyrogallol (10μM), a superoxide generator, induced an "aging-like" increase in AGEs, and direct treatment with AGEs induced vascular stiffening; these effects were prevented by incubation with sodium nitrite. De-stiffening of aged large elastic arteries by short-term sodium nitrite therapy is mediated in part by normalization of AGEs secondary to amelioration of oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.