ReviewMicrocirculation (New York, N.Y. : 1994)2012
What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?
Review in Microcirculation (New York, N.Y. : 1994), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Development of thin-film micro-outlets for spatially constraining local POFrontiers in physiology · 2025Article
- Skeletal muscle microvascular hemodynamic responses during hyperinsulinemic-euglycemic clamp in a Zucker Diabetic Sprague Dawley rat model of type 2 diabetes.Frontiers in physiology · 2025Article
- Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Heterogeneous ATP patterns in microvascular networks.Journal of the Royal Society, Interface · 2023Article
- The Effects of Two Weeks of Oral PeakATPJournal of functional morphology and kinesiology · 2023Article
- Pannexin1: insight into inflammatory conditions and its potential involvement in multiple organ dysfunction syndrome.Frontiers in immunology · 2023Review
- The role of the microcirculation and integrative cardiovascular physiology in the pathogenesis of ICU-acquired weakness.Frontiers in physiology · 2023Review
- Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model.Scientific reports · 2022Article
- Post-occlusive reactive hyperemia and skeletal muscle capillary hemodynamics.Microvascular research · 2022Article
- Dynamics of capillary blood flow responses to acute local changes in oxygen and carbon dioxide concentrations.Frontiers in physiology · 2022Article
- Red blood cells under flow show maximal ATP release for specific hematocrit.Biophysical journal · 2021Article
- Regenerated Microvascular Networks in Ischemic Skeletal Muscle.Frontiers in physiology · 2021Article
- Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle.Acta physiologica (Oxford, England) · 2016Review
- Finite Element Model of Oxygen Transport for the Design of Geometrically Complex Microfluidic Devices Used in Biological Studies.PloS one · 2016Article
- Blood cells: an historical account of the roles of purinergic signalling.Purinergic signalling · 2015Review
- Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries.Critical care (London, England) · 2015Article
- Red cell physiology and signaling relevant to the critical care setting.Current opinion in pediatrics · 2015Review
- Effects of oral adenosine-5'-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men.Nutrition & metabolism · 2013Article
- Modeling steady state SO2-dependent changes in capillary ATP concentration using novel O2 micro-delivery methods.Frontiers in physiology · 2013Article
- Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets.Journal of the International Society of Sports Nutrition · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Erythrocytes appear to be ideal sensors for regulating microvascular O(2) supply as they release the potent vasodilator ATP in an O(2) saturation-dependent manner. Whether erythrocytes play a significant role in regulating O(2) supply in the complex environment of diffusional O(2) exchange among capillaries, arterioles, and venules, depends on the efficiency with which erythrocytes signal the vascular endothelium. If one assumes that the distribution of purinergic receptors is uniform throughout the microvasculature, then the most efficient site for signaling should occur in capillaries, where the erythrocyte membrane is in close proximity to the endothelium. ATP released from erythrocytes would diffuse a short distance to P(2y) receptors inducing an increase in blood flow, possibly the result of endothelial hyperpolarization. We hypothesize that this hyperpolarization varies across the capillary bed depending upon erythrocyte supply rate and the flux of O(2) from these erythrocytes to support O(2) metabolism. This would suggest that the capillary bed would be the most effective site for erythrocytes to communicate tissue oxygen needs. Electrically coupled endothelial cells conduct the integrated signal upstream where arterioles adjust vascular resistance, thus enabling ATP released from erythrocytes to regulate the magnitude and distribution of O(2) supply to individual capillary networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.