ArticleMicrocirculation (New York, N.Y. : 1994)2012
Structural remodeling of the mouse gracilis artery: coordinated changes in diameter and medial area maintain circumferential stress.
Article in Microcirculation (New York, N.Y. : 1994), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Experimental and theoretical model of microvascular network remodeling and blood flow redistribution following minimally invasive microvessel laser ablation.Scientific reports · 2024Article
- Article
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Role of Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis.International journal of molecular sciences · 2021Review
- Arteriogenesis in murine adipose tissue is contingent on CD68Microcirculation (New York, N.Y. : 1994) · 2017Article
- Macrophage Recruitment and Polarization During Collateral Vessel Remodeling in Murine Adipose Tissue.Microcirculation (New York, N.Y. : 1994) · 2016Article
- Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- A method for longitudinal, transcranial imaging of blood flow and remodeling of the cerebral vasculature in postnatal mice.Physiological reports · 2014Article
- Dynamic adaption of vascular morphology.Frontiers in physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveVascular networks respond to chronic alterations in blood supply by structural remodeling. Previously, we showed that blood flow changes in the mouse GA lead to transient diameter increases, which can generate large increases in circumferential wall stress. Here, we examine the associated changes in the medial area of the arterial wall and the effects on circumferential wall stress.
methodsTo induce blood flow changes, one of the two feeding vessels to the GA was surgically removed. At 7-56 days after blood flow interruption, the vasculature was perfused with India ink for morphological measurements, and processed for immuno-cytochemistry to mark the medial cross-section area. Theoretical simulations of hemodynamics were used to analyze the data.
resultsDuring adaptive increases in vessel diameter, increases in medial area were observed, most strongly in the middle region of the artery. Simulations showed that this increase in medial area limits the increase in estimated circumferential stress during vascular adaptation to less than 50%, in contrast to an increase of up to 250% if the medial area had remained unchanged.
conclusionsDuring vascular adaptation, increases in circumferential stress are limited by growth of the media coordinated with diameter changes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.