Evidence map›Paper›PMID 22586568›Full record

ArticleCancer discovery2011

Unraveling the role of hypoxia-inducible factor in renal cell carcinoma: a biological and therapeutic perspective.

Sumanta Kumar Pal, Robert A Figlin

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cancer discovery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sumanta Kumar PalDivision of Genitourinary Malignancies, Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Robert A Figlin
City of Hope · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic control of hypoxia-inducible factor (HIF) has long been associated with the pathogenesis of clear cell renal cell carcinoma. Only recently have the complex genetics and biology of relevant HIF subtypes been unraveled, leading to potential novel strategies for treating this disease.

Indexed as

Chromosomes, Human, Pair 14Genes, Tumor SuppressorAnimalsCarcinoma, Renal CellHumansHypoxia-Inducible Factor 1, alpha SubunitKidney NeoplasmsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha Subunit

Identifiers

PMID22586568
OpenAlexW2141502624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.