ArticleFrontiers in physiology2012
Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Trypsin in pancreatitis: The culprit, a mediator, or epiphenomenon?World journal of gastroenterology · 2024Review
- ECRG2/SPINK7 Tumor Suppressor as Modulator of DNA Damage Response.International journal of molecular sciences · 2024Review
- Autophagy and the pancreas: Healthy and disease states.Frontiers in cell and developmental biology · 2024Review
- Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin.International journal of molecular sciences · 2022Article
- SPINKs in Tumors: Potential Therapeutic Targets.Frontiers in oncology · 2022Review
- Functional Roles of SPINK1 in Cancers.International journal of molecular sciences · 2021Review
- Male Decapacitation Factor SPINK3 Blocks Membrane Hyperpolarization and Calcium Entry in Mouse Sperm.Frontiers in cell and developmental biology · 2020Article
- SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes.EMBO molecular medicine · 2017Article
- Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.Scientific reports · 2016Article
- Article
- Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats.International journal of medical sciences · 2016Article
- The genetic predisposition and its impact on the diabetes mellitus development in patients with alcoholic chronic pancreatitis.Gastroenterology research and practice · 2015Article
- Cell death and DAMPs in acute pancreatitis.Molecular medicine (Cambridge, Mass.) · 2014Review
- Endoplasmic reticulum stress is chronically activated in chronic pancreatitis.The Journal of biological chemistry · 2014Article
- Article
- Recent advances in pancreatology.Frontiers in physiology · 2014Article
- Association of CTRC and SPINK1 gene variants with recurrent hospitalizations for pancreatitis or acute abdominal pain in lipoprotein lipase deficiency.Frontiers in genetics · 2014Article
- Generation and analysis of serine protease inhibitor kazal type 3-cre driver mice.Experimental animals · 2014Article
- New insights into the pathogenesis of pancreatitis.Current opinion in gastroenterology · 2013Review
- Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice.Gastroenterology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies on hereditary pancreatitis have provided evidence in favor of central role for trypsin activity in the disease. Identification of genetic variants of trypsinogen linked the protease to the onset of pancreatitis, and biochemical characterization proposed an enzymatic gain of function as the initiating mechanism. Mutations of serine protease inhibitor Kazal type 1 gene (SPINK1) are shown to be associated with hereditary pancreatitis. We previously reported that Spink3 (a mouse homolog gene of human SPINK1) deficient mice showed excessive autophagy, followed by inappropriate trypsinogen activation in the exocrine pancreas. These data indicate that the role of SPINK1/Spink3 is not only trypsin inhibitor, but also negative regulator of autophagy. On the other hand, recent studies showed that high levels of SPINK1 protein detected in a serum or urine were associated with adverse outcome in various cancer types. It has been suggested that expression of SPINK1 and trypsin is balanced in normal tissue, but this balance could be disrupted during tumor progression. Based on the structural similarity between SPINK1 and epidermal growth factor (EGF), we showed that SPINK1 protein binds and activates EGF receptor, thus acting as a growth factor on tumor cell lines. In this review, we summarize the old and new roles of SPINK1/Spink3 in trypsin inhibition, autophagy, and cancer cell growth. These new functions of SPINK1/Spink3 may be related to the development of chronic pancreatitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.