ArticleCancer discovery2011
The BATTLE trial: a bold step toward improving the efficiency of biomarker-based drug development.
Article in Cancer discovery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells.Molecular carcinogenesis · 2016Article
- Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.Nature reviews. Cancer · 2015Review
- The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research.Molecular oncology · 2015Review
- Clinical Trials in Non-Small Cell Lung Cancer with Biomarker-Driven Treatment Allocation: Ready or Not, Here We Come.Critical reviews in oncogenesis · 2015Review
- Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor.Cancer cell international · 2014Article
- Adaptive Clinical Trials: Overview of Early-Phase Designs and Challenges.Therapeutic innovation & regulatory science · 2014Article
- Biomarkers and sustainable innovation in cardiovascular drug development: lessons from near and far afield.Current atherosclerosis reports · 2013Review
- Cancer biomarkers: selecting the right drug for the right patient.Nature reviews. Drug discovery · 2012Review
- Adaptive clinical trial designs for simultaneous testing of matched diagnostics and therapeutics.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
Corrections and comments
- Comment on
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful completion of the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial, reported in this issue of Cancer Discovery, is an important advance in the effort to improve clinical trial approaches to the simultaneous development of new therapeutics with matching diagnostic tests so that patients most likely to benefit from these therapies can be identified.
Indexed as
Identifiers
22586314What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.