ArticleMolecular and cellular biology2012
Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- In silico analysis of the possible crosstalk between O-linked β-GlcNAcylation and phosphorylation sites of Disabled 1 adaptor protein in vertebrates.Amino acids · 2023Article
- Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.International journal of molecular sciences · 2021Article
- RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.Molecular and cellular biology · 2018Article
- AP-2ε Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells.Scientific reports · 2018Article
- Alternative Splicing in Neurogenesis and Brain Development.Frontiers in molecular biosciences · 2018Review
- The identification of switch-like alternative splicing exons among multiple samples with RNA-Seq data.PloS one · 2017Article
- A proteogenomic approach to understand splice isoform functions through sequence and expression-based computational modeling.Briefings in bioinformatics · 2016Article
- The neurogenetics of alternative splicing.Nature reviews. Neuroscience · 2016Review
- The emerging era of genomic data integration for analyzing splice isoform function.Trends in genetics : TIG · 2014Review
- Reelin-Disabled-1 signaling in neuronal migration: splicing takes the stage.Cellular and molecular life sciences : CMLS · 2013Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Disabled-1 (Dab1) plays a key role in reelin-mediated neuronal migration during brain development. Tyrosine phosphorylation of Dab1 at two YQXI and two YXVP motifs recruits multiple SH2 domains, resulting in activation of a wide range of signaling cascades. However, the molecular mechanisms underlying the coordinated regulation of Dab1 downstream effectors remain poorly understood. Here, we show that alternative splicing results in inclusion of different combinations of YQXI and YXVP motifs in Dab1 isoforms during development. Dab1 variants with partial or complete loss of YQXI motifs are preferentially expressed at early developmental stages, whereas the commonly studied Dab1 is predominantly expressed at late developmental stages. Expression of Dab1 variants in 293T and Neuro2a cells reveals reduced levels or absence of tyrosine phosphorylation in variants that have lost one or both YQXI motifs. We further demonstrate that Dab1 variants differ in their abilities to activate Src and recruit distinct SH2 domains involved in specific downstream signaling pathways. We propose that coordinated expression of specific Dab1 isoforms in different populations of cells in the developing brain contributes to precise neuronal migration by modulating the activity of subsets of Dab1 downstream effectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.