ArticleMolecular and cellular biology2012
Dynamic reconfiguration of long human genes during one transcription cycle.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- Optimization of Genome Knock-In Method: Search for the Most Efficient Genome Regions for Transgene Expression in Plants.International journal of molecular sciences · 2022Review
- Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer.Frontiers in cell and developmental biology · 2022Review
- The roles of inducible chromatin and transcriptional memory in cellular defense system responses to redox-active pollutants.Free radical biology & medicine · 2021Review
- Mechanisms of enhancer action: the known and the unknown.Genome biology · 2021Review
- Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner.The EMBO journal · 2020Article
- Forces driving the three-dimensional folding of eukaryotic genomes.Molecular systems biology · 2018Review
- SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription.Molecular cell · 2018Article
- Higher-Order Chromatin Regulation of Inflammatory Gene Expression.Mediators of inflammation · 2017Review
- Binding of nuclear factor κB to noncanonical consensus sites reveals its multimodal role during the early inflammatory response.Genome research · 2016Article
- Chromatin architecture underpinning transcription elongation.Nucleus (Austin, Tex.) · 2016Review
- Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.Molecular cell · 2016Article
- Morphology of nuclear transcription.Histochemistry and cell biology · 2016Review
- CTCF-mediated chromatin loops enclose inducible gene regulatory domains.BMC genomics · 2016Article
- Dynamic enhancer-gene body contacts during transcription elongation.Genes & development · 2015Article
- TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.Genome biology · 2014Article
- Article
- The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.Journal of cellular physiology · 2014Review
- RNA polymerase II transcription elongation control.Chemical reviews · 2013Review
- De novo mutations in the genome organizer CTCF cause intellectual disability.American journal of human genetics · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We analyzed three human genes that were >200 kbp in length as they are switched on rapidly and synchronously by tumor necrosis factor alpha and obtained new insights into the transcription cycle that are difficult to obtain using continuously active, short, genes. First, a preexisting "whole-gene" loop in one gene disappears on stimulation; it is stabilized by CCCTC-binding factor and TFIIB and poises the gene for a prompt response. Second, "subgene" loops (detected using chromosome conformation capture) develop and enlarge, a result that is simply explained if elongating polymerases become immobilized in transcription factories, where they reel in their templates. Third, high-resolution localization confirms that relevant nascent transcripts (detected using RNA fluorescence in situ hybridization) lie close enough to be present on the surface of one factory. These dynamics underscore the complex transitions between the poised, initiating, and elongating transcriptional states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.