ArticleAnnals of the rheumatic diseases2013
Childhood socioeconomic factors and perinatal characteristics influence development of rheumatoid arthritis in adulthood.
Article in Annals of the rheumatic diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Socioeconomic inequality in patients with rheumatoid arthritis: a systematic review and meta-analysis.Clinical rheumatology · 2021Pooled it
- Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis.Arthritis research & therapy · 2015Pooled it
- Birth length and perinatal exposures and rheumatoid arthritis risk in the E3N cohort.RMD open · 2026Observational
- The Ability of Indigenous Plants in Alleviating Rheumatoid Arthritis: A Comprehensive Review.Current rheumatology reviews · 2025Review
- Family History of Arthritis, Osteoporosis, and Carpal Tunnel Syndrome and Risk of These Conditions Among US Adults.Arthritis care & research · 2024Article
- Article
- [Influence of smoking, nutrition and other modifiable environmental factors on rheumatoid arthritis].Zeitschrift fur Rheumatologie · 2024Review
- Causal effects of time-varying body size on selected autoimmune disorders: a life course Mendelian randomisation study.RMD open · 2023Observational
- Article
- Lifestyle Factors and Their Influence on Rheumatoid Arthritis: A Narrative Review.Journal of clinical medicine · 2022Review
- Birthweight and subsequent risk for thyroid and autoimmune conditions in postmenopausal women.Journal of developmental origins of health and disease · 2022Article
- Management of Rheumatoid Arthritis: An Overview.Cells · 2021Review
- Etiology and Risk Factors for Rheumatoid Arthritis: A State-of-the-Art Review.Frontiers in medicine · 2021Review
- Effects of Language, Insurance, and Race/Ethnicity on Measurement Properties of the PROMIS Physical Function Short Form 10a in Rheumatoid Arthritis.Arthritis care & research · 2019Article
- Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice.Cellular & molecular immunology · 2019Article
- Geographic variation in incidence and prevalence rates for rheumatoid arthritis in Saskatchewan, Canada 2001-2014.Canadian journal of public health = Revue canadienne de sante publique · 2018Article
- Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult-Onset Rheumatoid Arthritis in Women.American journal of epidemiology · 2018Article
- A meta-analysis of the relationship between body mass index and risk of rheumatoid arthritis.EXCLI journal · 2018Article
- Maternal and Perinatal Exposures Are Associated With Risk for Pediatric-Onset Multiple Sclerosis.Pediatrics · 2017Article
- Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis.Annals of the rheumatic diseases · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRheumatoid arthritis (RA) has been associated with lower socioeconomic status (SES), but the reasons for this are not known.
objectiveTo examine childhood SES measures, SES trajectory and other perinatal factors in relation to RA.
methodsThe sample included 50 884 women, aged 35-74 (84% non-Hispanic white) enrolled 2004-9 in a US national cohort study. In baseline questionnaires, cases (N=424, 0.8%) reported RA diagnosis after age 16, ever use of disease-modifying antirheumatic drugs or steroids for RA and ≥6 weeks bilateral joint swelling. Childhood SES measures are presented as OR and 95% CI adjusted for age and race/ethnicity. Analyses of perinatal factors also adjusted for childhood SES, and joint effects of childhood and adult SES and smoking exposures were evaluated.
resultsPatients with RA reported lower childhood household education (<12 years vs college degree; OR=1.7; 95% CI 1.1 to 2.5), food insecurity (OR=1.5, 95% CI 1.1 to 2.0) and young maternal age (<20 vs 20-34 years; OR=1.7, 95% CI 1.2 to 2.5), with a trend (p<0.0001) for increasing number of adverse factors (OR=3.0; 95% CI 1.3 to 7.0; 4 vs 0 factors) compared with non-cases. Low birth weight (<2500 g) [corrected] and preconception paternal smoking were independently associated with RA. Together, lower childhood SES and adult education (<college degree) were associated with RA (interaction p=0.03), with a joint effect magnitude similar to a history of paternal and adult smoking.
conclusionsRA was associated with low childhood SES sustained into adulthood, with cumulative effects across multiple measures, suggesting the importance of other unmeasured factors linking SES and RA.
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