ReviewAdvances in nutrition (Bethesda, Md.)2012
Profiles of human milk oligosaccharides and production of some human milk oligosaccharides in transgenic animals.
Review in Advances in nutrition (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Biosynthesis of human milk oligosaccharides (HMOs) in glycoengineered human cells.Glycobiology · 2026Article
- Infant formulas with synthetic oligosaccharides and respective marketing practices.Molecular and cellular pediatrics · 2022Article
- Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers: Lewis Positive Secretor Subgroups.Journal of agricultural and food chemistry · 2018Article
- Purification of caprine oligosaccharides at pilot-scale.Journal of food engineering · 2017Article
- Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers.Nutrients · 2016Observational
- Lectin-based analysis of fucosylated glycoproteins of human skim milk during 47 days of lactation.Glycoconjugate journal · 2015Article
- Human Milk Oligosaccharides (HMOS): Structure, Function, and Enzyme-Catalyzed Synthesis.Advances in carbohydrate chemistry and biochemistry · 2015Review
- Milk, dairy products, and their functional effects in humans: a narrative review of recent evidence.Advances in nutrition (Bethesda, Md.) · 2014Review
- Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants.PloS one · 2014Article
- Introduction to the symposium.Advances in nutrition (Bethesda, Md.) · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the decade of the 1990s and the first years of the current century, our group embarked on a project to study and synthesize human milk oligosaccharides. This report describes 2 unexpected collateral observations from that endeavor. The first observation was the detection and confirmation of 2 rare neutral human milk oligosaccharides profiles that were uncovered while assessing oligosaccharide content in hundreds of samples of human milk. One of these lacked fucosylated structures altogether, and the other lacked the oligosaccharide 3-fucosyllactose [Galβ1-4(Fucα1-3)Glc]. We used glycoconjugate probes to determine whether the unusual profiles were mirrored by fucosylation of milk glycoproteins. The results show that the lack of fucosylated oligosaccharides in these samples corresponds to the absence of equivalent fucosylated motifs in milk glycoproteins. The second finding was a shortened and distinct lactation process in transgenic rabbits expressing the human fucosyltransferase 1. During the first day of lactation, these animals expressed milk that contained both lactose and 2'-fucosylactose, but on the second day, the production of milk was severely diminished, and by the fourth day, no lactose was detected in their milk. Meanwhile, the concentration of fucosylated glycoproteins increased from the onset of lactation through its premature termination. These 2 findings may shed light on the glycobiology of milk and perhaps on mammary gland differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.