ArticleThe Journal of experimental medicine2012
Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
Article in The Journal of experimental medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed.
- Combating respiratory diseases with mucosal vaccines.Journal of virology · 2026Review
- Nanoparticle-Based Pulmonary Immune Engineering.Annual review of chemical and biomolecular engineering · 2025Review
- Tissue-Resident Th2 Cells in Type 2 Immunity and Allergic Diseases.Immunological reviews · 2025Review
- Immunomodulatory biomaterials for treating chronic inflammation at mucosal sites.npj biomedical innovations · 2025Review
- Lung Immune Cell Niches and the Discovery of New Cell Subtypes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Immediate myeloid depot for SARS-CoV-2 in the human lung.Science advances · 2024Article
- Slicing through the challenge of maintainingmBio · 2024Article
- The role of DC subgroups in the pathogenesis of asthma.Frontiers in immunology · 2024Review
- Non-mucosal vaccination strategies to enhance mucosal immunity.Vaccine insights · 2023Article
- A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma.Science immunology · 2023Article
- Expansion of Phenotypically Altered Dendritic Cell Populations in the Small Airways and Alveolar Parenchyma in Patients with Chronic Obstructive Pulmonary Disease.Journal of innate immunity · 2023Article
- Insights into dendritic cell maturation during infection with application of advanced imaging techniques.Frontiers in cellular and infection microbiology · 2023Review
- Article
- Immediate myeloid depot for SARS-CoV-2 in the human lung.Research square · 2022Article
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- Macropinocytosis and Cell Migration: Don't Drink and Drive….Sub-cellular biochemistry · 2022Article
- Layilin Anchors Regulatory T Cells in Skin.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma.Respiratory research · 2021Article
- Strategy to enhance dendritic cell-mediated DNA vaccination in the lung.Advanced therapeutics · 2021Article
- Dendritic Cells: Critical Regulators of Allergic Asthma.International journal of molecular sciences · 2020Review
47 more citing papers are in PubMed but not listed here.
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8 authors.
Funding
Abstract
Asthma pathogenesis is focused around conducting airways. The reasons for this focus have been unclear because it has not been possible to track the sites and timing of antigen uptake or subsequent antigen presentation to effector T cells. In this study, we use two-photon microscopy of the lung parenchyma and note accumulation of CD11b(+) dendritic cells (DCs) around the airway after allergen challenge but very limited access of these airway-adjacent DCs to the contents of the airspace. In contrast, we observed prevalent transepithelial uptake of particulate antigens by alveolar DCs. These distinct sites are temporally linked, as early antigen uptake in alveoli gives rise to DC and antigen retention in the airway-adjacent region. Antigen-specific T cells also accumulate in the airway-adjacent region after allergen challenge and are activated by the accumulated DCs. Thus, we propose that later airway hyperreactivity results from selective retention of allergen-presenting DCs and antigen-specific T cells in airway-adjacent interaction zones, not from variation in the abilities of individual DCs to survey the lung.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.