ArticleJournal of physiology and biochemistry2012
Effect of zinc supplementation on type 2 diabetes parameters and liver metallothionein expressions in Wistar rats.
Article in Journal of physiology and biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effect of Zinc Supplementation on Lipid Profiles in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Effects of maternal Cu, Mn, and Zn supplementation from different sources on physiological and productive responses of cows and their offspring.Journal of animal science · 2025Article
- A formulation containingBeilstein journal of nanotechnology · 2025Article
- Supplementation of Siberian sturgeon (Acipenser baerii) diet with different zinc sources: effects on growth performance, digestive enzymes activity, hemato-biochemical parameters, antioxidant response and liver histology.Veterinary research communications · 2024Article
- Influence of Lemongrass Essential Oil (Life (Basel, Switzerland) · 2024Article
- Beneficial effects of Se/Zn co-supplementation on body weight and adipose tissue inflammation in high-fat diet-induced obese rats.Food science & nutrition · 2021Article
- Supplementing organic-complexed or inorganic Co, Cu, Mn, and Zn to beef cows during gestation: postweaning responses of offspring reared as replacement heifers or feeder cattle.Journal of animal science · 2021Article
- Supplementing organic-complexed or inorganic Co, Cu, Mn, and Zn to beef cows during gestation: physiological and productive response of cows and their offspring until weaning.Journal of animal science · 2021Article
- Zinc.Advances in food and nutrition research · 2021Review
- Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway.Journal of diabetes research · 2021Article
- Protection against diabetic cardiomyopathy is achieved using a combination of sulforaphane and zinc in type 1 diabetic OVE26 mice.Journal of cellular and molecular medicine · 2019Article
- Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism.The journal of physiological sciences : JPS · 2018Review
- Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy.Diabetes · 2017Article
- Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2015Review
- Electric Pulse Stimulation of Myotubes as an In Vitro Exercise Model: Cell-Mediated and Non-Cell-Mediated Effects.Scientific reports · 2015Article
- Antioxidant role of zinc in diabetes mellitus.World journal of diabetes · 2015Review
- Article
- Feeding low or pharmacological concentrations of zinc oxide changes the hepatic proteome profiles in weaned piglets.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is a trace metal and acts as an active component of various enzymes. Zinc deficiency has been suggested to be associated with the development of diabetes. The present study investigated the role of zinc supplementation on prevention of diabetic conditions. A double-disease model mimicking hyperlipidemia and type 2 diabetes was created by applying high-fat diet and streptozotocin (STZ) to Wistar rats. We demonstrated that zinc supplementation improved symptoms of diabetes such as polydipsia and increased serum level of high-density lipoprotein cholesterol, indicating that zinc supplementation has a potential beneficial effect on diabetic conditions. The level of maldondialdehyde (MDA), an oxidative stress marker, was reduced in liver by zinc supplementation in high fat-fed rats with or without STZ injection. Meanwhile, we observed an increase in the expression of metallothioneins (MTs) in liver of rats treated with zinc. This suggests that the induction of MTs in liver, which has been shown to be important in scavenging free radicals, could be one of the underlying mechanisms of zinc supplementation on reducing MDA levels in liver. Finally, we found that zinc levels in liver were increased while there was no change in serum zinc levels, indicating that local zinc level might be a critical factor for the induction of MTs. Also, the level of MTs could potentially be an index of zinc bioavailability. Taken together, these results suggest that both zinc and MT could play an important role in balancing nutrition and metabolism to prevent diabetic development.
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Registered trials
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