ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2012
N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- The Protective Effects of N-Acetylserotonin Against Cisplatin-Induced Renal Injury: A Biochemical and Histopathological Study.International journal of molecular sciences · 2026Article
- Review
- Molecules in the Serotonin-Melatonin Synthesis Pathway Have Distinct Interactions with Lipid Membranes.The journal of physical chemistry. B · 2025Article
- Partners in health and disease: pineal gland and purinergic signalling.Purinergic signalling · 2025Review
- Identification of a serotonin N-acetyltransferase fromFrontiers in microbiology · 2023Article
- Possible Role of Pineal and Extra-Pineal Melatonin in Surveillance, Immunity, and First-Line Defense.International journal of molecular sciences · 2021Review
- Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector Effect.BioMed research international · 2021Article
- The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe?Biomolecules · 2020Review
- Insect ArylalkylamineFrontiers in molecular biosciences · 2018Review
- Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress.Molecules (Basel, Switzerland) · 2016Review
- Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2016Review
- Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.The Journal of biological chemistry · 2016Article
- The Retina and Other Light-sensitive Ocular Clocks.Journal of biological rhythms · 2016Review
- Comparison of melatonin with growth factors in promoting precursor cells proliferation in adult mouse subventricular zone.EXCLI journal · 2016Article
- Future Directions for Pharmacotherapies for Treatment-resistant Bipolar Disorder.Current neuropharmacology · 2015Review
- A time to remember: the role of circadian clocks in learning and memory.Behavioral neuroscience · 2014Review
- N-acetyl-serotonin protects HepG2 cells from oxidative stress injury induced by hydrogen peroxide.Oxidative medicine and cellular longevity · 2014Article
- Protective effect of N-acetylserotonin against acute hepatic ischemia-reperfusion injury in mice.International journal of molecular sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
N-Acetylserotonin (NAS) is a naturally occurring chemical intermediate in biosynthesis of melatonin. Previous studies have shown that NAS has different brain distribution patterns from those of serotonin and melatonin, suggesting that NAS might have functions other than as a precursor or metabolite of melatonin. Indeed, several studies have now shown that NAS may play an important role in mood regulation and may have antidepressant activity. Additional studies have shown that NAS stimulates proliferation of neuroprogenitor cells and prevents some of the negative effects of sleep deprivation. It is believed that the antidepressant and neurotrophic actions of NAS are due at least in part to the capability on this molecule to activate the TrkB receptor in a brain-derived neurotrophic factor-independent manner. Emerging evidence also indicates that NAS and its derivatives have neuroprotective properties and protect retinal photoreceptor cells from light-induced degeneration. In this review, the authors discuss the literature about this exciting and underappreciated molecule.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.