Trial reportJournal of psychopharmacology (Oxford, England)2012
Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images.
Trial report in Journal of psychopharmacology (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The effects of cannabis use on salience attribution: a systematic review.Acta neuropsychiatrica · 2018Pooled it
- Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress.Drug and alcohol dependence · 2017Trial
- Cannabinoid Modulation of Frontolimbic Activation and Connectivity During Volitional Regulation of Negative Affect.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled study in cannabis users.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Trial
- Trial
- Pre-encoding administration of amphetamine or THC preferentially modulates emotional memory in humans.Psychopharmacology · 2013Trial
- Acute and delayed effects of THC on memories of stress in healthy adults.Psychopharmacology · 2026Article
- Cognitive Effects of Cannabis Use: A Comprehensive Review Across Domains.Neurology international · 2025Review
- The Hallucinogen Rating Scale: Updated Factor Structure in a Large, Multistudy Sample.Biological psychiatry global open science · 2025Article
- Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia.Schizophrenia bulletin · 2023Review
- Cannabinoid extract in microdoses ameliorates mnemonic and nonmnemonic Alzheimer's disease symptoms: a case report.Journal of medical case reports · 2022Article
- The why behind the high: determinants of neurocognition during acute cannabis exposure.Nature reviews. Neuroscience · 2021Review
- Cannabis and Cognitive Functioning: From Acute to Residual Effects, From Randomized Controlled Trials to Prospective Designs.Frontiers in psychiatry · 2021Review
- Effects of ∆BMC psychiatry · 2020Review
- Chronic Use of Synthetic Cannabinoids Is Associated With Impairment in Working Memory and Mental Flexibility.Frontiers in psychiatry · 2020Article
- Developing a phone-based measure of impairment after acute oral ∆Journal of psychopharmacology (Oxford, England) · 2019Article
- Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation.Frontiers in behavioral neuroscience · 2019Article
- Intrinsic Frontolimbic Connectivity and Mood Symptoms in Young Adult Cannabis Users.Frontiers in public health · 2019Article
- Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors.Scientific reports · 2017Article
- Effects of levodopa-carbidopa-entacapone and smoked cocaine on facial affect recognition in cocaine smokers.Journal of psychopharmacology (Oxford, England) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
There is growing evidence that drugs of abuse alter processing of emotional information in ways that could be attractive to users. Our recent report that Δ⁹-tetrahydrocannabinol (THC) diminishes amygdalar activation in response to threat-related faces suggests that THC may modify evaluation of emotionally-salient, particularly negative or threatening, stimuli. In this study, we examined the effects of acute THC on evaluation of emotional images. Healthy volunteers received two doses of THC (7.5 and 15 mg; p.o.) and placebo across separate sessions before performing tasks assessing facial emotion recognition and emotional responses to pictures of emotional scenes. THC significantly impaired recognition of facial fear and anger, but it only marginally impaired recognition of sadness and happiness. The drug did not consistently affect ratings of emotional scenes. THC's effects on emotional evaluation were not clearly related to its mood-altering effects. These results support our previous work, and show that THC reduces perception of facial threat. Nevertheless, THC does not appear to positively bias evaluation of emotional stimuli in general.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.