Evidence map›Paper›PMID 22584905›Full record

ReviewThe Journal of cell biology2012

Spectraplakins: master orchestrators of cytoskeletal dynamics.

Kathleen C Suozzi, Xiaoyang Wu, Elaine Fuchs

Abstract readReview
In one paragraph

Review in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed.

  1. Article
  2. Alterations of actin in aging.Journal of cell science · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Identification ofJournal of medical genetics · 2025
    Article
  8. A Multifaceted Giant Protein Microtubule-Actin Cross-Linking Factor 1.International journal of molecular sciences · 2025
    Review
  9. A missense mutation in theJournal of medicine and life · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Review
  16. Article
  17. TheMolecular biology of the cell · 2022
    Article
  18. Cross-linkers at growing microtubule ends generate forces that drive actin transport.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kathleen C SuozziThe Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Xiaoyang Wu
Elaine Fuchs

Funding

GENE EXPRESSION AND DIFFERENTIATION IN HUMAN EPIDERMISR37AR027883 · NIAMS · UNIVERSITY OF CHICAGO · PI ELAINE FUCHS · 1994 to 2026
$13.3M
GENE EXPRESSION &DIFFERENTIATION IN HUMAN EPIDERMISR01AR027883 · NIAMS · UNIVERSITY OF CHICAGO · PI FUCHS, ELAINE · 1986 to 2022
$7.6M
Howard Hughes Medical InstituteNIAMS NIH HHS R01 AR027883NIAMS NIH HHS (R01-AR27883NIAMS NIH HHS R37 AR027883
6 · The paper itself

Abstract

The dynamics of different cytoskeletal networks are coordinated to bring about many fundamental cellular processes, from neuronal pathfinding to cell division. Increasing evidence points to the importance of spectraplakins in integrating cytoskeletal networks. Spectraplakins are evolutionarily conserved giant cytoskeletal cross-linkers, which belong to the spectrin superfamily. Their genes consist of multiple promoters and many exons, yielding a vast array of differential splice forms with distinct functions. Spectraplakins are also unique in their ability to associate with all three elements of the cytoskeleton: F-actin, microtubules, and intermediate filaments. Recent studies have begun to unveil their role in a wide range of processes, from cell migration to tissue integrity.

Indexed as

ActinsCell MovementCytoskeletal ProteinsCytoskeletonHumansSpectrinActinsCytoskeletal ProteinsSpectrin

Identifiers

PMID22584905
PMCPMC3352950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.