Evidence map›Paper›PMID 22584777›Full record

ArticleJournal of pediatric hematology/oncology2012

Cardiac failure 30 years after treatment containing anthracycline for childhood acute lymphoblastic leukemia.

John M Goldberg, Rebecca E Scully, Stephen E Sallan, Steven E Lipshultz

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric hematology/oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John M GoldbergDepartment of Pediatrics, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA.
Rebecca E Scully
Stephen E Sallan
Steven E Lipshultz

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
Zebrafish Screens for Genetic Modifiers and Human Application in T-ALLP01CA068484 · NCI · DANA-FARBER CANCER INSTITUTE · PI GILLILAND, GARY L. · 1995 to 2010
$31.9M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
PEDIATRIC CARDIOMYOPATHY REGISTRYR01HL053392 · NHLBI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 1995 to 2009
$8.3M
Cardiovascular Status of HAART-Exposed Infants/ChildrenR01HL072705 · NHLBI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 2002 to 2006
$5.6M
Cardiac Biomarkers in Pediatric CardiomyopathyR01HL109090 · NHLBI · WAYNE STATE UNIVERSITY · PI ROSS, ROBERT D. · 2012 to 2016
$5.3M
TRAINING PROGRAMS IN CARDIOVASCULAR PHARMACOLOGYT32HL007188 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SZCZESNA-CORDARY, DANUTA · 1985 to 2011
$3.8M
Women and Infants Transmission Study IVU01AI050274 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RICH, KENNETH C · 2001 to 2005
$3.6M
Pediatric Cardiomyopathy Specimen RepositoryR01HL087000 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TOWBIN, JEFFREY ALLEN · 2007 to 2010
$2.2M
HAART Associated Cardiotoxicity in HIV-Infected ChildrenR01HL078522 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIPSHULTZ, STEVEN EDWARD · 2004 to 2008
$2.0M
Atherosclerotic Risk and Response to Exercise Intervention in HIV+ ChildrenR01HL095127 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MILLER, TRACIE L · 2008 to 2010
$1.1M
CARDIAC RISK FACTORS IN PEDIATRIC CANCER SURVIVORSR01CA079060 · NCI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 1998 to 2002
$1.1M
NCI NIH HHS CA068484NCI NIH HHS CA127642NCI NIH HHS P01 CA068484NCI NIH HHS R01 CA079060NCI NIH HHS R01 CA127642NHLBI NIH HHS F31 HL094100NHLBI NIH HHS HL004537NHLBI NIH HHS HL007188NHLBI NIH HHS HL053392NHLBI NIH HHS HL072705NHLBI NIH HHS HL078522NHLBI NIH HHS HL079233NHLBI NIH HHS HL087000NHLBI NIH HHS HL087708NHLBI NIH HHS HL094100NHLBI NIH HHS HL095127NHLBI NIH HHS K30 HL004537NHLBI NIH HHS R01 HL053392NHLBI NIH HHS R01 HL072705NHLBI NIH HHS R01 HL078522NHLBI NIH HHS R01 HL087000NHLBI NIH HHS R01 HL095127NHLBI NIH HHS R01 HL109090NHLBI NIH HHS R13 HL087708NHLBI NIH HHS T32 HL007188NIAID NIH HHS AI50274NIAID NIH HHS U01 AI050274NICHD NIH HHS HD052102NICHD NIH HHS HD052104NICHD NIH HHS HD80002NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104
6 · The paper itself

Abstract

In 1977, a 5-year-old girl diagnosed with acute lymphoblastic leukemia was treated on Dana-Farber Cancer Institute Childhood Acute Lymphoblastic Leukemia Protocol 77-01, receiving a cumulative doxorubicin dose of 465 mg/m(2), cranial radiation, and other drugs. After being in continuous complete remission for 34 months, she developed heart failure and was treated with digoxin and furosemide. At 16 years of age, she was diagnosed and treated for dilated cardiomyopathy. Over the years, she continued to have bouts of heart failure, which became less responsive to treatment. At 36 years of age, she received a heart transplant. Six months later, she stopped taking her medications and suffered a sudden cardiac death.

Indexed as

Antibiotics, AntineoplasticChild, PreschoolDoxorubicinFemaleHeart FailureHumansPrecursor Cell Lymphoblastic Leukemia-LymphomaAntibiotics, AntineoplasticDoxorubicin

Identifiers

PMID22584777
PMCPMC3380184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.