ReviewJournal of assisted reproduction and genetics2012
Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances.
Review in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- Elagolix Alone or With Add-Back Therapy in Women With Heavy Menstrual Bleeding and Uterine Leiomyomas: A Randomized Controlled Trial.Obstetrics and gynecology · 2018Trial
- The application of tissue engineering strategies for uterine regeneration.Materials today. Bio · 2025Review
- Abnormal Uterine Bleeding With Leiomyomas: A Case Report of Its Natural Course and Therapeutic Management.Cureus · 2024Article
- Beyond the learning curve: improving outcomes in Robotic myomectomy compared to laparoscopic myomectomy.Journal of robotic surgery · 2023Article
- Analysis of risk factors for postoperative bleeding and recurrence after laparoscopic myomectomy in patients with uterine fibroids: a retrospective cohort study.Gland surgery · 2023Article
- Endometrial Sampling for Preoperative Diagnosis of Uterine Leiomyosarcoma.Journal of minimally invasive gynecology · 2022Article
- Identification of PDGFRα+ cells in uterine fibroids - link between angiogenesis and uterine telocytes.Archives of medical science : AMS · 2022Article
- Effects of total laparoscopic hysterectomy on the clinical outcomes of patients with uterine fibroids.American journal of translational research · 2022Article
- Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview.Clinical pharmacokinetics · 2022Review
- Prognostic value of the location of submucosal uterine leiomyomas in infertility.Experimental and therapeutic medicine · 2021Article
- Uterine leiomyomas revisited with review of literature.Abdominal radiology (New York) · 2021Review
- Organotypic culture as a research and preclinical model to study uterine leiomyomas.Scientific reports · 2020Article
- Transcervical Radiofrequency Ablation of Symptomatic Uterine Fibroids: 2-Year Results of the SONATA Pivotal Trial.Journal of gynecologic surgery · 2019Article
- Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.The Journal of biological chemistry · 2018Article
- Uterine Fibroids: Burden and Unmet Medical Need.Seminars in reproductive medicine · 2017Review
- Halofuginone suppresses growth of human uterine leiomyoma cells in a mouse xenograft model.Human reproduction (Oxford, England) · 2016Article
- Transforming growth factor-β signaling pathway cross-talking with ERα signaling pathway on regulating the growth of uterine leiomyoma activated by phenolic environmental estrogens in vitro.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Case series: Pregnancy Outcome in Patients with Uterine Fibroids.Journal of clinical and diagnostic research : JCDR · 2015Article
- Use of Chinese medicine correlates negatively with the consumption of conventional medicine and medical cost in patients with uterine fibroids: a population-based retrospective cohort study in Taiwan.BMC complementary and alternative medicine · 2015Article
- Injectable Clostridium histolyticum collagenase as a potential treatment for uterine fibroids.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeUterine leiomyomas are common, benign, reproductive tract tumors affecting a majority of reproductive aged women. They are associated with gynecologic morbidity and detrimentally affect reproductive potential. The etiology of leiomyomas is poorly understood and their diagnosis prior to treatment with Assisted Reproductive Technologies (ART) represents a management dilemma. The purpose of this paper is to review known genetic and molecular contributions to the etiologies of leiomyomas, describe their impact on ART outcomes and reproductive potential, and review alternative therapies and future directions in management.
methodsA critical review of the literature pertaining to genetic component of uterine leiomyomas, their impact on ART and pregnancy and leiomyoma therapeutics was performed.
resultsUterine leiomyomas are characterized by complex molecular mechanisms. Their location and size determines their potential detriment to ART and reproductive function and novel therapeutic modalities are being developed.
conclusionThe high prevalence of uterine leiomyomas and their potential detrimental influence on ART and reproductive function warrants continued well-designed studies to ascertain their etiology, optimal treatment and novel less morbid therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.