ArticleToxicological sciences : an official journal of the Society of Toxicology2012
Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Application of systematic evidence mapping to assess the impact of new research when updating health reference values: A case example using acrolein.Environment international · 2020Pooled it
- Welding Fumes, a Risk Factor for Lung Diseases.International journal of environmental research and public health · 2020Pooled it
- Intranasal drug delivery to the brain for neurodegenerative diseases: Current efforts and challenges in delivery platforms and modeling.Advanced drug delivery reviews · 2026Review
- Tactile learning and memory deficits following cigarette and e-cigarette exposure: neural alterations in the barrel cortex and hippocampus.Cognitive processing · 2026Article
- Simulation of drug transport in airway surface liquid considering mucus flow and ciliary interaction.Scientific reports · 2025Article
- Modeling aerosol bolus inhalations in the human lung with the Multiple Path Particle Deposition model: Comparison with experimental data.Journal of aerosol science · 2025Article
- Data on hydrodynamic flow and aspiration mechanisms in a patient-specific pharyngolaryngeal model with variable epiglottis angles.Data in brief · 2025Article
- Two- and Three-Dimensional Culture Systems: Respiratory In Vitro Tissue Models for Chemical Screening and Risk-Based Decision Making.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Subject-Specific Multi-Scale Modeling of the Fate of Inhaled Aerosols.Journal of aerosol science · 2025Article
- Oropharyngeal swallowing hydrodynamics of thin and mildly thick liquids in an anatomically accurate throat-epiglottis model.Scientific reports · 2024Article
- A Cell-Based Nasal Model for Screening the Deposition, Biocompatibility, and Transport of Aerosolized PLGA Nanoparticles.Molecular pharmaceutics · 2024Article
- An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models.Particle and fibre toxicology · 2023Article
- Nasal anatomy and sniffing in respiration and olfaction of wild and domestic animals.Frontiers in veterinary science · 2023Review
- Differential transcriptomic alterations in nasal versus lung tissue of acrolein-exposed rats.Frontiers in toxicology · 2023Article
- Computational fluid dynamics comparison of the upper airway velocity, pressure, and resistance in cats using an endotracheal tube or a supraglottic airway device.Frontiers in veterinary science · 2023Article
- Salbutamol transport and deposition in healthy cat airways under different breathing conditions and particle sizes.Frontiers in veterinary science · 2023Article
- Article
- Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung.Toxicology · 2022Article
- A comprehensive physiologically based pharmacokinetic (PBPK) model for nicotine in humans from using nicotine-containing products with different routes of exposure.Scientific reports · 2022Article
- Small Airway Susceptibility to Chemical and Particle Injury.Respiration; international review of thoracic diseases · 2022Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
Computational fluid dynamics (CFD) models are useful for predicting site-specific dosimetry of airborne materials in the respiratory tract and elucidating the importance of species differences in anatomy, physiology, and breathing patterns. We improved the imaging and model development methods to the point where CFD models for the rat, monkey, and human now encompass airways from the nose or mouth to the lung. A total of 1272, 2172, and 135 pulmonary airways representing 17±7, 19±9, or 9±2 airway generations were included in the rat, monkey and human models, respectively. A CFD/physiologically based pharmacokinetic model previously developed for acrolein was adapted for these anatomically correct extended airway models. Model parameters were obtained from the literature or measured directly. Airflow and acrolein uptake patterns were determined under steady-state inhalation conditions to provide direct comparisons with prior data and nasal-only simulations. Results confirmed that regional uptake was sensitive to airway geometry, airflow rates, acrolein concentrations, air:tissue partition coefficients, tissue thickness, and the maximum rate of metabolism. Nasal extraction efficiencies were predicted to be greatest in the rat, followed by the monkey, and then the human. For both nasal and oral breathing modes in humans, higher uptake rates were predicted for lower tracheobronchial tissues than either the rat or monkey. These extended airway models provide a unique foundation for comparing material transport and site-specific tissue uptake across a significantly greater range of conducting airways in the rat, monkey, and human than prior CFD models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.