ArticleBiomechanics and modeling in mechanobiology2013
Highly sensitive single-fibril erosion assay demonstrates mechanochemical switch in native collagen fibrils.
Article in Biomechanics and modeling in mechanobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Computational multiscale analysis of growth and remodeling in the ascending aorta of the Marfan mouse.Biomechanics and modeling in mechanobiology · 2026Article
- Geometric and mechanical changes along the length of the porcine aorta.Journal of biomechanics · 2026Article
- Biomechanical Variation of the Vessel Wall Along the Length of the Healthy Aorta-Linking Geometric, Flow-, and Pressure-Mediated Adaptations.Journal of biomechanical engineering · 2026Review
- Collagen Mechanics.Sub-cellular biochemistry · 2026Review
- In tendons, differing physiological requirements lead to distinct patterns of MMP-1 degradation.Scientific reports · 2025Article
- Microstructural remodeling under single fiber tensional homeostasis recreates distinctive ex vivo mechanical behavior of arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Article
- Modeling collagen fibril degradation as a function of matrix microarchitecture.bioRxiv : the preprint server for biology · 2024Article
- Mechanochemistry of collagen.Acta biomaterialia · 2023Review
- Mechanical strain modulates extracellular matrix degradation and byproducts in an isoform-specific manner.Biochimica et biophysica acta. General subjects · 2023Article
- Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues.Matrix biology : journal of the International Society for Matrix Biology · 2022Review
- Does the Heart Want What It Wants? A Case for Self-Adapting, Mechano-Sensitive Therapies After Infarction.Frontiers in cardiovascular medicine · 2021Article
- Investigation of Pathophysiological Aspects of Aortic Growth, Remodeling, and Failure Using a Discrete-Fiber Microstructural Model.Journal of biomechanical engineering · 2020Article
- Review
- Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for 'use it or lose it'.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- The Relationship Between Scleral Strain Change and Differential Cumulative Intraocular Pressure Exposure in the Nonhuman Primate Chronic Ocular Hypertension Model.Investigative ophthalmology & visual science · 2019Article
- Models of tendon development and injury.BMC biomedical engineering · 2019Article
- Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Adaptive Remodeling of Achilles Tendon: A Multi-scale Computational Model.PLoS computational biology · 2016Article
- Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
It has been established that the enzyme susceptibility of collagen, the predominant load-bearing protein in vertebrates, is altered by applied tension. However, whether tensile force increases or decreases the susceptibility to enzyme is a matter of contention. It is critical to establish a definitive understanding of the direction and magnitude of the force versus catalysis rate (k C ) relationship if we are to properly interpret connective tissue development, growth, remodeling, repair, and degeneration. In this investigation, we examine collagen/enzyme mechanochemistry at the smallest scale structurally relevant to connective tissue: the native collagen fibril. A single-fibril mechanochemical erosion assay with nN force resolution was developed which permits detection of the loss of a few layers of monomer from the fibril surface. Native type I fibrils (bovine) held at three levels of tension were exposed to Clostridium histolyticum collagenase A. Fibrils held at zero-load failed rapidly and consistently (20 min) while fibrils at 1.8 pN/monomer failed more slowly (35-55 min). Strikingly, fibrils at 23.9 pN/monomer did not exhibit detectable degradation. The extracted force versus k C data were combined with previous single-molecule results to produce a "master curve" which suggests that collagen degradation is governed by an extremely sensitive mechanochemical switch.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.