ArticleClinical research in cardiology : official journal of the German Cardiac Society2012
Automated photoplethysmography-based determination of ankle-brachial index: a validation study against Doppler sonography.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Validation of a New Ankle Brachial Index Measurement System Using Pulse Wave Velocity.Biosensors · 2024Article
- Does the advantage of transcutaneous oximetry measurements in diabetic foot ulcer apply equally to free flap reconstruction?World journal of clinical cases · 2023Article
- Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study.Journal of clinical medicine · 2023Article
- Assessment of the systolic rise time by photoplethysmography in peripheral arterial diseases: a comparative study with ultrasound Doppler.European heart journal open · 2022Article
- Automated Measurements of Ankle-Brachial Index: A Narrative Review.Journal of clinical medicine · 2021Review
- Innovative Multi-Site Photoplethysmography Analysis for Quantifying Pulse Amplitude and Timing Variability Characteristics in Peripheral Arterial Disease.Diseases (Basel, Switzerland) · 2018Article
- Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population.Atherosclerosis · 2017Article
- Predictive value of the augmentation index derived vascular age in patients with newly diagnosed atherosclerosis.Heart and vessels · 2017Article
- Ankle brachial index for the diagnosis of lower limb peripheral arterial disease.The Cochrane database of systematic reviews · 2016Review
- Observational
- Automated plethysmographic measurement of the ankle-brachial index: a comparison with the doppler ultrasound method.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- The value of noncoronary atherosclerosis for identifying coronary artery disease: results of the Leipzig LIFE Heart Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany.BMC public health · 2015Article
- Validity, intra- and inter-observer reliability of automated devices for the assessment of ankle brachial index using photo-plethysmography.BMC cardiovascular disorders · 2013Article
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8 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionDetermination of ankle-brachial-index (ABI) by manual Doppler is well established to screen for lower extremity arterial disease (LEAD) and to predict cardiovascular risk. A new generation of digital-controlled devices promises automated ABI determination. The aim of this study was to determine comparability of automated photoplethysmography (PPG)-derived ABI calculation with the Doppler-ABI algorithm commonly used in cohort studies.
methodsAutomated PPG-based ABI measurements [Vascular Explorer (VE) and Vicorder (VI)] were recorded from 112 limbs of healthy subjects and 22 limbs of patients with confirmed LEAD. Validity was evaluated on the basis of receiver-operating characteristic (ROC) analysis of clinical status and concordance with Doppler-ABI. Differences between cuff inflation [inf]- and deflation [def]-based method were studied in VE.
resultsPPG-based ABI values were higher compared to Doppler-ABI (VI +0.06, VEinf +0.15, VEdef +0.09, p < 0.001, respectively). The difference was pronounced in pathological (<0.9), borderline (0.9-0.99) and low normal (1.0-1.09) ABI, but less in ABI ≥1.1. However, ROC analysis revealed excellent diagnostic value for LEAD (sensitivity/specificity) and comparable area under the curve at method-adapted ABI thresholds for all methods: Doppler (95/90 %, 0.95), VI (75/96 %, 0.91), VEinf (85/89 %, 0.93) and VEdef (80/98 %, 0.94).
conclusionsDigital-controlled PPG-based ABI determination is a useful diagnostic application for LEAD. However, the systematic higher ABI in PPG-based measurement compared to Doppler and remarkable differences between the deflationary and inflationary method are critical for the interpretation of borderline and low normal ABI values where precise reading is essential to detect mild LEAD and subclinical disease and to predict cardiovascular risk.
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