ArticleFEBS letters2012
Drosophila Bicoid is a substrate of sumoylation and its activator function is subject to inhibition by this post-translational modification.
Article in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Versatile roles of disordered transcription factor effector domains in transcriptional regulation.The FEBS journal · 2025Review
- A sensitive mNeonGreen reporter system to measure transcriptional dynamics in Drosophila development.Communications biology · 2020Article
- Article
- Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo.Development (Cambridge, England) · 2015Article
- Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila.Nature communications · 2013Article
- SUMOylation in Drosophila Development.Biomolecules · 2012Article
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Abstract
Bicoid (Bcd) is a Drosophila morphogenetic protein and a transcriptional activator. Genetic studies have suggested a role of sumoylation in Bcd function, but it is unknown how Bcd activity is affected specifically by its own sumoylation status. Here we show that Bcd is sumoylated in Drosophila cells. We identify a lysine residue of Bcd as the primary sumoylation site. Using a Bcd mutant defective in being sumoylated, we show that sumoylation of Bcd is inhibitory to its ability to activate transcription. We provide evidence suggesting that the SUMO moiety has an intrinsic inhibitory activity for the activator function of Bcd.
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