ArticleBMC gastroenterology2012
Vertebral fractures in patients with inflammatory bowel disease compared with a healthy population: a prospective case-control study.
Article in BMC gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02704624 (The Impact of Serum Vitamin D and Calcium Levels on the Body Composition, Bone Mineral Density, Muscle Strength, Exercise Tolerance, Fatigue and Inflammatory Activity in Patients With Crohn's Disease), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Serum Vitamin D and Calcium Levels on the Body Composition, Bone Mineral Density, Muscle Strength, Exercise Tolerance, Fatigue and Inflammatory Activity in Patients With Crohn's Disease: a Randomized Controlled Trial
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Inflammatory bowel disease and the risk of all caused or specific fracture: a meta-epidemiologic study.Frontiers in endocrinology · 2026Pooled it
- Prevalence of osteoporosis in patients with inflammatory bowel disease: a systematic review and meta-analysis.Journal of health, population, and nutrition · 2025Pooled it
- Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis.Inflammatory bowel diseases · 2015Pooled it
- Improvements in Bone Density and Structure during Anti-TNF-α Therapy in Pediatric Crohn's Disease.The Journal of clinical endocrinology and metabolism · 2015Trial
- Risk Factors for the Occurrence of Femoral Fractures in Inflammatory Bowel Disease Patients: A Nationwide Population-Based Cohort Study.Journal of clinical medicine · 2026Article
- The role of vitamin D deficiency and modifiable risk factors in patients with Crohn's disease.Frontiers in immunology · 2025Article
- Inflammatory bowel disease is associated with greater odds of complications following posterior lumbar fusion and further amplified for patients exposed to monoclonal antibody biologics.North American Spine Society journal · 2024Article
- High prevalence of vitamin D deficiency in Taiwanese patients with inflammatory bowel disease.Scientific reports · 2024Article
- Osteoporosis Complications in Crohn's Disease Patients: Factors, Pathogenesis, and Treatment Outlines.Cureus · 2021Review
- The risk of revision following total hip arthroplasty in patients with inflammatory bowel disease, a registry based study.PloS one · 2021Article
- Updated bone mineral density status in Saudi patients with inflammatory bowel disease.World journal of gastroenterology · 2020Article
- Perspective on skeletal health in inflammatory bowel disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Review
- Bone alterations in inflammatory bowel diseases.World journal of clinical cases · 2019Review
- Bone Mineral Loss and Fracture in Sarcoidosis: A Systematic Review and Meta-Analysis.Archives of rheumatology · 2019Article
- Bone mineral density and inflammatory bowel disease severity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures.European journal of pediatrics · 2017Article
- Risk of vertebral and non-vertebral fractures in patients with sarcoidosis: a population-based cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Pathological fractures in paediatric patients with inflammatory bowel disease.European journal of pediatrics · 2014Review
- Delays in puberty, growth, and accrual of bone mineral density in pediatric Crohn's disease: despite temporal changes in disease severity, the need for monitoring remains.The Journal of pediatrics · 2013Review
- Manipulating bone disease in inflammatory bowel disease patients.Annals of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA prospective study was performed to compare the prevalence of morphometric vertebral fractures (MVF) between patients with inflammatory bowel disease (IBD) and healthy subjects and to identify predictive factors of fracture.
methodsA total of 107 patients with IBD (53 with Crohn's disease and 54 with ulcerative colitis) and 51 healthy subjects participated in the study. Information about anthropometric parameters, toxins, previous fractures, and parameters related to this disease were evaluated. The index of vertebral deformity, bone mass density (BMD), and biochemical parameters were calculated.
resultsA total of 72 fractures were detected in 38.32% of patients with IBD, and 10 fractures were detected in 13.73% of healthy subjects; the risk of fracture in patients with IBD was higher than that in control subjects (OR, 4.03; 95% CI, 1.652-9.847; p < 0.002). We found no correlation between fracture and BMD in patients with IBD (lumbar spine, r = -0.103, p = 0.17 and femoral neck, r = -0.138, p = 0.07). Corticosteroid treatment was not associated with prevalent vertebral fractures nor with taking corticosteroids (r = 0.135, p = 0.14) or the duration for which they were taken (r = 0.08, p = 0.38), whereas this relationship was present in the controls (r = -0.365, p = 0.01). In the multivariate analysis, none of the measured parameters were significantly predictive of fracture, only to manifested IBD. Hypovitaminosis D was observed in 55.14% of patients with IBD.
conclusionsThe prevalence of morphometric vertebral fractures is higher in patients with IBD than in the healthy population, without association with BMD or corticoid treatment. Simply having IBD was proven to be a predictive factor of fracture. We observed a high incidence of hypovitaminosis D in patients with IBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.