ArticleBMC microbiology2012
Corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the C. diphtheriae NCTC 13129 prophage.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 58 citations in OpenAlex.
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- Comparative whole-genome analysis of diphtheria toxin-producing Corynebacterium ulcerans isolates from sheltered cats in Osaka, Japan.The Journal of veterinary medical science · 2023Article
- Complete Genome Sequence of Corynebacterium ulcerans Strain TSU-28, Harboring Two Diphtheria Toxin Genes, Isolated from a Patient with Diphtheria-Like Symptoms.Microbiology resource announcements · 2023Article
- Endemic erythromycin resistantMicrobial genomics · 2022Article
- Limitations of Ribotyping as Genotyping Method for Corynebacterium ulcerans.Emerging infectious diseases · 2020Article
- Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals.Antonie van Leeuwenhoek · 2020Article
- Mutation and Diversity of Diphtheria Toxin in Corynebacterium ulcerans.Emerging infectious diseases · 2019Article
- Characterization of Bacteria and Inducible Phages in an Intensive Care Unit.Journal of clinical medicine · 2019Article
- Genomic analyses reveal two distinct lineages ofNew microbes and new infections · 2018Article
- The first fatal case ofJMM case reports · 2017Article
- Comparative genomic analysis between Corynebacterium pseudotuberculosis strains isolated from buffalo.PloS one · 2017Article
- Draft Genome Sequence of Toxigenic Corynebacterium ulcerans Strain 03-8664 Isolated from a Human Throat.Genome announcements · 2016Article
- Genome Sequence of Corynebacterium ulcerans Strain FRC11.Genome announcements · 2015Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCorynebacterium ulcerans can cause a diphtheria-like illness, especially when the bacterium is lysogenized with a tox gene-carrying bacteriophage that produces diphtheria toxin. Acquisition of toxigenicity upon phage lysogenization is a common feature of C. ulcerans and C. diphtheriae. However, because of a lack of C. ulcerans genome information, a detailed comparison of prophages has not been possible between these two clinically important and closely related bacterial species.
resultsWe determined the whole genome sequence of the toxigenic C. ulcerans 0102 isolated in Japan. The genomic sequence showed a striking similarity with that of Corynebacterium pseudotuberculosis and, to a lesser extent, with that of C. diphtheriae. The 0102 genome contained three distinct prophages. One of these, ΦCULC0102-I, was a tox-positive prophage containing genes in the same structural order as for tox-positive C. diphtheriae prophages. However, the primary structures of the individual genes involved in the phage machinery showed little homology between the two counterparts.
conclusionTaken together, these results suggest that the tox-positive prophage in this strain of C. ulcerans has a distinct origin from that of C. diphtheriae NCTC 13129.
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