ArticleEcology letters2012
Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field.
Article in Ecology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
71 citing papers in PubMed, 187 citations in OpenAlex.
- Regional Lassa virus lineages select for divergent MHC-I repertoires in Mastomys natalensis rodents.PLoS pathogens · 2026Article
- Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex.Nature ecology & evolution · 2025Article
- Parasite-mediated inbreeding depression in wild red deer.Heredity · 2025Article
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- A Mosquito Parasite Is Locally Adapted to Its Host but Not Temperature.The American naturalist · 2024Article
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- Immunogenetic-pathogen networks shrink in Tome's spiny rat, a generalist rodent inhabiting disturbed landscapes.Communications biology · 2024Article
- HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Article
- Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania.Immunogenetics · 2023Article
- Seascape genomics reveals limited dispersal and suggests spatially varying selection among European populations of sea lamprey (Evolutionary applications · 2023Article
- Ecological Speciation Promoted by Divergent Regulation of Functional Genes Within African Cichlid Fishes.Molecular biology and evolution · 2022Article
- Relationship between genome-wide and MHC class I and II genetic diversity and complementarity in a nonhuman primate.Ecology and evolution · 2022Article
- Contemporary selection on MHC genes in a free-living ruminant population.Ecology letters · 2022Article
- Divergent and non-parallel evolution of MHC IIB in the Neotropical Midas cichlid species complex.BMC ecology and evolution · 2022Article
- Genomic and environmental influences on resilience in a cold-water fish near the edge of its range.Evolutionary applications · 2021Article
- Functional immunogenetic variation, rather than local adaptation, predicts ectoparasite infection intensity in a model fish species.Molecular ecology · 2021Article
- Sick of eating: Eco-evo-immuno dynamics of predators and their trophically acquired parasites.Evolution; international journal of organic evolution · 2021Article
- Rapid adaptation through genomic and epigenomic responses following translocations in an endangered salmonid.Evolutionary applications · 2021Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major histocompatibility complex (MHC) with its key function in parasite resistance represents an ideal candidate to investigate parasite-mediated local adaptation. Using replicated field mesocosms, stocked with second-generation lab-bred three-spined stickleback hybrids of a lake and a river population, we show local adaptation of MHC genotypes to population-specific parasites, independently of the genetic background. Increased allele divergence of lake MHC genotypes allows lake fish to fight the broad range of lake parasites, whereas more specific river genotypes confer selective advantages against the less diverse river parasites. Hybrids with local MHC genotype gained more body weight and thus higher fitness than those with foreign MHC in either habitat, suggesting the evolutionary significance of locally adapted MHC genotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.