ArticleJournal of translational medicine2012
Increased HOX C13 expression in metastatic melanoma progression.
Article in Journal of translational medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- The HOX Gene Family's Role as Prognostic and Diagnostic Biomarkers in Hematological and Solid Tumors.Cancers · 2025Review
- HOXC13 promotes cell proliferation, metastasis and glycolysis in breast cancer by regulating DNMT3A.Experimental and therapeutic medicine · 2023Article
- Variants Identified in theGenes · 2023Article
- Identification and validation of a novel HOX-related classifier signature for predicting prognosis and immune microenvironment in pediatric gliomas.Frontiers in cell and developmental biology · 2023Article
- Molecular implications of HOX genes targeting multiple signaling pathways in cancer.Cell biology and toxicology · 2022Review
- Gut Microbiota Dysbiosis Induced by Decreasing Endogenous Melatonin Mediates the Pathogenesis of Alzheimer's Disease and Obesity.Frontiers in immunology · 2022Article
- Aberrant Expression of Long Non Coding RNA HOTAIR and De-Regulation of the Paralogous 13 HOX Genes Are Strongly Associated with Aggressive Behavior of Gastro-Entero-Pancreatic Neuroendocrine Tumors.International journal of molecular sciences · 2021Article
- LncRNA HOTAIR Promotes Proliferation of Malignant Melanoma Cells through NF-ϰB Pathway.Iranian journal of public health · 2020Article
- HOXC10 is significantly overexpressed in colorectal cancer.Biomedical reports · 2020Article
- Article
- Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer.Oncology letters · 2020Article
- Paralogous HOX13 Genes in Human Cancers.Cancers · 2019Review
- Posterior HOX genes and HOTAIR expression in the proximal and distal colon cancer pathogenesis.Journal of translational medicine · 2018Article
- HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription of CASP3.Cancer science · 2018Article
- Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer.Translational oncology · 2017Article
- Establishment and genomic characterization of primary salivary duct carcinoma cell line.Oral oncology · 2017Article
- A four gene signature predictive of recurrent prostate cancer.Oncotarget · 2017Article
- HOXC13 promotes proliferation of lung adenocarcinoma via modulation of CCND1 and CCNE1.American journal of cancer research · 2017Article
- The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma.Oncotarget · 2016Article
- ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe process of malignant transformation, progression and metastasis of melanoma is not completely understood. Recently, the microarray technology has been used to survey transcriptional differences that might provide insight into the metastatic process, but the validation of changing gene expression during metastatic transition period is poorly investigated. A large body of literature has been produced on the role of the HOX genes network in tumour evolution, suggesting the involvement of HOX genes in several types of human cancers. Deregulated paralogous group 13 HOX genes expression has been detected in melanoma, cervical cancer and odonthogenic tumors. Among these, Hox C13 is also involved in the expression control of the human keratin genes hHa5 and hHa2, and recently it was identified as a member of human DNA replication complexes.
methodsIn this study, to investigate HOX C13 expression in melanoma progression, we have compared its expression pattern between naevi, primary melanoma and metastasis. In addition HOXC13 profile pattern of expression has been evaluated in melanoma cell lines.
resultsOur results show the strong and progressive HOX C13 overexpression in metastatic melanoma tissues and cytological samples compared to nevi and primary melanoma tissues and cells.
conclusionsThe data presentated in the paper suggest a possible role of HOX C13 in metastatic melanoma switch.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.