ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Noninvasive evaluation of skeletal muscle mitochondrial capacity with near-infrared spectroscopy: correcting for blood volume changes.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 112 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-invasive Evaluation of Muscle Oxidative Capacity. Study of Its Relationship With Muscular Endurance and Fatigue in Patients With Multiple Sclerosis
Near-Infrared Spectroscopy-Derived Mitochondrial Oxidative Phosphorylation Capacity, Local Muscular Fatigue Resistance, and the Effects of Acute Taurine Supplementation
Who cites it
112 citing papers in PubMed, 225 citations in OpenAlex.
- Histamine-receptor blockade does not influence the heavy-severe domain boundary and time to task failure in the severe domain during cycling exercise in adults.Physiological reports · 2025Trial
- Effectiveness of short-term cycling interventions in older adults: a randomized trial of hypoxic, blood flow restriction, and eccentric cycling.Scientific reports · 2025Trial
- Cardiorespiratory Fitness Improvements Following Low-Frequency Training Are Not Inferior to High-Frequency Training Matched for Intensity and Volume.Scandinavian journal of medicine & science in sports · 2025Trial
- Body mass-normalized moderate dose of dietary nitrate intake improves endothelial function and walking capacity in patients with peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Trial
- Muscle mitochondrial capacity in high- and low-fitness females using near-infrared spectroscopy.Physiological reports · 2021Trial
- Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Mitochondria-specific antioxidant supplementation does not influence endurance exercise training-induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake.The Journal of physiology · 2016Trial
- Skeletal muscle microvascular and respiratory responses to exercise in healthy and T2D adults: agreement and reproducibility study of NIRS technologies.European journal of applied physiology · 2026Article
- Time-resolved energy-share reconstruction of individual glycolytic flux kinetics reveals duration-dependent bias in elite sprint cycling.European journal of applied physiology · 2026Article
- Near infrared spectroscopy-derived muscle oxidative capacity correlates to oxidative metabolic predictors of performance in highly trained female middle-distance runners.Physiological reports · 2026Article
- Quadriceps Muscle Length Differentially Affects Exercise Capacity, the Torque-Duration Relationship, and Neuromuscular Fatigue.Scandinavian journal of medicine & science in sports · 2026Article
- Bed rest decreases resting skeletal muscle OExperimental physiology · 2026Article
- Peak oxygen consumption is positively associated with estimates of oxygen extraction and microvascular blood volume in veterans with chronic kidney disease.American journal of physiology. Renal physiology · 2026Article
- The impact of muscle oxidative capacity on neuromuscular recovery after exercise-induced muscle damage.European journal of applied physiology · 2026Article
- Muscle oxidative capacity does not appear to influence NIRS-VOT outcomes in healthy adults.European journal of applied physiology · 2026Article
- Change in mitochondrial capacity in elite triathletes, cyclists, and wrestlers over a training period of 28 days.European journal of applied physiology · 2026Article
- Steepest near-infrared spectroscopy-derived deoxygenation slopes during arterial occlusions provide more reliable assessments of muscle mitochondrial capacity.Experimental physiology · 2026Article
- Evaluation of Muscle Oxygenation Responses to Eccentric Exercise and Recovery Enhancement Using Capacitive-Resistive Electric Transfer and Vibration Therapy.Journal of clinical medicine · 2026Article
- Assessment of muscle oxygenation following eccentric exercise-induced muscle damage using near-infrared spectroscopy.PloS one · 2026Article
- NIRS-Derived Muscle Deoxygenation During Arterial Occlusion at Rest Before and After Body Weight Resistance Training with Slow Movement and Tonic Force Generation.Advances in experimental medicine and biology · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Near-infrared spectroscopy (NIRS) is a well-known method used to measure muscle oxygenation and hemodynamics in vivo. The application of arterial occlusions allows for the assessment of muscle oxygen consumption (mVo(2)) using NIRS. The aim of this study was to measure skeletal muscle mitochondrial capacity using blood volume-corrected NIRS signals that represent oxygenated hemoglobin/myoglobin (O(2)Hb) and deoxygenated hemoglobin/myoglobin (HHb). We also assessed the reliability and reproducibility of NIRS measurements of resting oxygen consumption and mitochondrial capacity. Twenty-four subjects, including four with chronic spinal cord injury, were tested using either the vastus lateralis or gastrocnemius muscles. Ten healthy, able-bodied subjects were tested on two occasions within a period of 7 days to assess the reliability and reproducibility. NIRS signals were corrected for blood volume changes using three different methods. Resting oxygen consumption had a mean coefficient of variation (CV) of 2.4% (range 1-32%). The recovery of oxygen consumption (mVo(2)) after electrical stimulation at 4 Hz was fit to an exponential curve, which represents mitochondrial capacity. The time constant for the recovery of mVo(2) was reproducible with a mean CV of 10% (range 1-22%) only when correcting for blood volume changes. We also examined the effects of adipose tissue thickness on measurements of mVo(2). We found the mVo(2) measurements using absolute units to be influenced by adipose tissue thickness (ATT), and this relationship was removed when an ischemic calibration was performed, supporting its use to compare mVo(2) between individuals of varying ATT. In conclusion, in vivo oxidative capacity can be assessed using blood volume-corrected NIRS signals with a high degree of reliability and reproducibility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.