ArticleAmerican journal of respiratory and critical care medicine2012
Prenatal and postnatal maternal stress and wheeze in urban children: effect of maternal sensitization.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00269256 (Stress, Environment, and Genetics in Urban Asthma), which is not on this map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress, Environment, and Genetics in Urban Asthma
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies.Allergy · 2016Pooled it
- Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation.Scientific reports · 2016Trial
- Longitudinally investigating patterns of maternal psychological distress in a South African birth cohort.BMC public health · 2025Article
- Asthma: Biomedical and Psychobiological Perspectives.Biopsychosocial science and medicine · 2025Review
- Combined effects of traffic-related air pollution, climate factors, and greenness on respiratory disease risk in infants.Scientific reports · 2025Article
- Maternal mental health disorders associate with their child's asthma: A register-based study.Brain, behavior, & immunity - health · 2025Article
- Antenatal depressive and anxiety symptoms in early pregnancy and offspring allergic diseases during toddlerhood.World journal of pediatrics : WJP · 2025Article
- Moderate-to-late prematurity: understanding respiratory consequences and modifiable risk factors.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Epigenetic Insights into Autism Spectrum Disorder: DNA Methylation Levels ofClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Maternal stressful life events during pregnancy and childhood asthma and wheeze.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Duration of exposure to epidural anesthesia at delivery, DNA methylation in umbilical cord blood and their association with offspring asthma in Non-Hispanic Black women.Environmental epigenetics · 2023Article
- Brain-Airway Interactions in Asthma.Advances in experimental medicine and biology · 2023Article
- Longitudinal assessment of maternal depression and early childhood asthma and wheeze: Effect modification by child sex.Pediatric pulmonology · 2023Article
- Trajectories of neighborhood environmental factors and their associations with asthma symptom trajectories among children in Australia: evidence from a national birth cohort study.Journal of environmental health science & engineering · 2022Article
- Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study.BMC pregnancy and childbirth · 2022Article
- Associations Between Maternal Distress During Early Life Periods and Offspring Respiratory Infections and Allergic Outcomes.Frontiers in pediatrics · 2022Article
- Maternal prenatal psychological distress associates with offspring early-life wheezing - FinnBrain Birth Cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Multi-Level Socioenvironmental Contributors to Childhood Asthma in New York City: a Cluster Analysis.Journal of urban health : bulletin of the New York Academy of Medicine · 2021Article
- Prenatal Neighborhood Ethnocultural Context and the Mental Health of Mothers and Children in Low-Income Mexican American Families.Child development · 2021Article
- Maternal stress and depression are associated with respiratory phenotypes in urban children.The Journal of allergy and clinical immunology · 2021Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
rationaleCritical periods for programming early wheeze risk may include pregnancy and infancy. Effects of timing remain poorly understood.
objectivesAssociations among prenatal and postnatal maternal stress and children's wheeze were prospectively examined in 653 families. Effect modification by maternal sensitization was also examined.
methodsStress was indexed by a maternal negative life events (NLEs) score (range, 0-9) ascertained during pregnancy and between 1 and 2 years postpartum. Mothers reported child wheeze every 3 months up to age 2 years. Relationships of prenatal and postnatal maternal NLEs with repeated wheeze (≥2 episodes) were examined using logistic regression adjusting for covariates. Penalized splines were implemented to explore possible nonlinear associations. We also examined the interaction between prenatal stress and maternal sensitization indexed by allergen-specific IgE from maternal prenatal serum. MEASUREMENTS AND MAIN
resultsAdjusted models considering prenatal or postnatal NLEs alone both showed an exposure-response relationship between higher stress and child wheeze. When considering prenatal and postnatal stress concurrently, only children of mothers with high stress in both periods were significantly more likely to wheeze (adjusted odds ratio, 3.04; 95% confidence interval, 1.67-5.53) than children of mothers reporting low stress in both periods. Associations between high prenatal stress and wheeze were significant in children born to nonsensitized mothers (any IgE <0.35 kU/L) but not in the sensitized group (P for interaction = 0.03).
conclusionsAlthough children have heightened sensitivity to maternal stress in utero and in early childhood, those with higher stress in both periods were particularly at risk for wheeze. The prenatal maternal immune milieu modified effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.