ArticleACS chemical neuroscience2012
Small Molecule Induction of Human Umbilical Stem Cells into MBP-positive Oligodendrocytes in a Defined Three-Dimensional Environment.
Article in ACS chemical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis.Journal of neuroinflammation · 2023Article
- Article
- Mechanical regulation of oligodendrocyte biology.Neuroscience letters · 2020Review
- Hemmule: A Novel Structure with the Properties of the Stem Cell Niche.International journal of molecular sciences · 2020Article
- Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus.PloS one · 2020Article
- Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS.Scientific reports · 2015Article
- In vitro and in vivo neurogenic potential of mesenchymal stem cells isolated from different sources.Journal of biosciences · 2014Review
- Myelination and node of Ranvier formation on sensory neurons in a defined in vitro system.In vitro cellular & developmental biology. Animal · 2013Article
- Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Microphysiological systems and low-cost microfluidic platform with analytics.Stem cell research & therapy · 2013Review
- Converted neural cells: induced to a cure?Protein & cell · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Stem cells from umbilical cord would be a favorable alternative to embryonic stem cells for therapeutic applications. In this study, human multipotent progenitor cells (MLPCs) from umbilical cord were differentiated into oligodendrocytes by exposure to a range of microenvironmental chemical and physical cues. Chemical cues were represented by a novel defined differentiation medium containing the neurotransmitter norepinephrine (NE). In traditional 2 dimensional (2D) conditions, the MLPCs differentiated into oligodendrocyte precursors, but did not progress further. However, in a 3 dimensional (3D) environment, the MLPCs differentiated into committed oligodendrocytes that expressed MBP. The apparent method of interaction of NE in stimulating the differentiation process was identified to occur through the adenergic pathway while all prior differentiation methods have used other routes. This novel method of obtaining functional human oligodendrocytes from MLPCs would eliminate many of the difficulties associated with their differentiation from embryonic stem cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.