ArticlePlant physiology2012
Gene silencing in Arabidopsis spreads from the root to the shoot, through a gating barrier, by template-dependent, nonvascular, cell-to-cell movement.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Dexamethasone-inducible LhGR/pOp system: simple and flexible spatiotemporal control of gene expression.Planta · 2026Review
- Three decades of mobile RNA silencing within plants: what have we learnt?Journal of experimental botany · 2026Review
- New insights into plasmodesmata: complex 'protoplasmic connecting threads'.Journal of experimental botany · 2024Review
- Plant gene silencing signals move from the phloem to influence gene expression in shoot apical meristems.BMC plant biology · 2022Article
- A correlative light electron microscopy approach reveals plasmodesmata ultrastructure at the graft interface.Plant physiology · 2022Article
- Root-to-Shoot Long-Distance Mobile miRNAs Identified fromInternational journal of molecular sciences · 2021Article
- Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species.Planta · 2021Article
- HASTY, the Arabidopsis EXPORTIN5 ortholog, regulates cell-to-cell and vascular microRNA movement.The EMBO journal · 2021Article
- Secondary siRNAs in Plants: Biosynthesis, Various Functions, and Applications in Virology.Frontiers in plant science · 2021Review
- A Sequential Three-Phase Pathway Constitutes Tracheary Element Connection in theFrontiers in plant science · 2021Article
- Unidirectional movement of small RNAs from shoots to roots in interspecific heterografts.Nature plants · 2021Article
- Interspecific grafting between Gossypium hirsutum, G. barbadense and G. herbaceum lines.Scientific reports · 2020Article
- Movement of small RNAs in and between plants and fungi.Molecular plant pathology · 2020Review
- Application of Exogenous dsRNAs-induced RNAi in Agriculture: Challenges and Triumphs.Frontiers in plant science · 2020Review
- The Whys and Wherefores of Transitivity in Plants.Frontiers in plant science · 2020Review
- Insights Into Plant Surgery: An Overview of the Multiple Grafting Techniques forFrontiers in plant science · 2020Review
- Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Small RNA Mobility: Spread of RNA Silencing Effectors and its Effect on Developmental Processes and Stress Adaptation in Plants.International journal of molecular sciences · 2019Review
- Systemic signalling through translationally controlled tumour protein controls lateral root formation in Arabidopsis.Journal of experimental botany · 2019Article
- Methods for graftingPlant methods · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upward long-distance mobile silencing has been shown to be phloem mediated in several different solanaceous species. We show that the Arabidopsis (Arabidopsis thaliana) seedling grafting system and a counterpart inducible system generate upwardly spreading long-distance silencing that travels not in the phloem but by template-dependent reiterated short-distance cell-to-cell spread through the cells of the central stele. Examining the movement of the silencing front revealed a largely unrecognized zone of tissue, below the apical meristem, that is resistant to the silencing signal and that may provide a gating or protective barrier against small RNA signals. Using a range of auxin and actin transport inhibitors revealed that, in this zone, alteration of vesicular transport together with cytoskeleton dynamics prevented or retarded the spread of the silencing signal. This suggests that small RNAs are transported from cell to cell via plasmodesmata rather than diffusing from their source in the phloem.
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