ArticleThe open microbiology journal2012
Survey of Virulence Determinants among Vancomycin Resistant Enterococcus faecalis and Enterococcus faecium Isolated from Clinical Specimens of Hospitalized Patients of North west of Iran.
Article in The open microbiology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Molecular Characterization of Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Molecular Characterization ofArchives of Razi Institute · 2023Article
- Virulence genes and antimicrobial resistance in Enterococcus strains isolated from dogs and cats in Northeast China.The Journal of veterinary medical science · 2023Article
- Virulence gene detection and antimicrobial resistance analysis of Enterococcus faecium in captive giant pandas (Ailuropoda melanoleuca) in China.Acta veterinaria Scandinavica · 2023Article
- Emergence of OptrA Gene Mediated Linezolid Resistance among Enterococcus Faecium: A Pilot Study from a Tertiary Care Hospital, India.International journal of molecular and cellular medicine · 2023Article
- Antibiogram Pattern and Virulence Trait Characterization ofJournal of laboratory physicians · 2022Article
- Prevalence, Antibiotic Resistance and Virulence ofEthiopian journal of health sciences · 2022Article
- Review
- Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance.Pathogens (Basel, Switzerland) · 2021Review
- Molecular epidemiology of vancomycin-resistantPeerJ · 2021Article
- Linezolid-resistant Enterococcus faecium strains isolated from one hospital in Poland -commensals or hospital-adapted pathogens?PloS one · 2020Article
- Epidemiology of Vancomycin-ResistantOpen forum infectious diseases · 2020Article
- Antimicrobial resistance pattern, virulence determinants and molecular analysis of Enterococcus faecium isolated from children infections in Iran.BMC microbiology · 2019Article
- Prevalence of biofilm formation and vancomycin-resistant genes amongIranian journal of microbiology · 2018Article
- Virulence Determinants and Antimicrobial Resistance Patterns of Vancomycin-resistantIranian journal of public health · 2018Article
- Antimicrobial resistance patterns and virulence factors of enterococci isolates in hospitalized burn patients.BMC research notes · 2018Article
- Molecular detection ofInfection and drug resistance · 2018Article
- Biochemical and physiological responses of halophilic nanophytoplankton (Dunaliella salina) from exposure to xeno-estrogen 17α-ethinylestradiol.Environmental science and pollution research international · 2017Article
- Correlation between Infective Factors and Antibiotic Resistance inChonnam medical journal · 2017Article
- Assessment of virulence potential of uncharacterized Enterococcus faecalis strains using pan genomic approach - Identification of pathogen-specific and habitat-specific genes.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent data indicates an increasing rate of vancomycin resistance in clinical enterococcal isolates worldwide. The nosocomial enterococci are likely to harbor virulence elements that increase their ability to colonize hospitalized patients. The aim of this study was to characterize virulence determinants in vancomycin-resistant enterococci (VRE) obtained from various clinical sources.During the years 2008 to 2010, a total of 48 VRE isolates were obtained from three University teaching hospitals in Northwest, Iran. Initially, phenotypic speciation was done and minimum inhibitory concentrations (MICs) of vancomycin were determined by agar dilution method and E-test. Then, species identification and resistance genotypes along with detection of virulence genes (asa1, esp, gelE, ace and cpd) of the isolates were performed by multiplex PCR.Thirty eight isolates were identified as vancomycin-resistant Enterococcus faecium (VREfm) and ten as E. faecalis (VREfs). Irrespective of the species, vanA gene (89.58%) was dominant and three phenotypically vancomycin susceptible E. faecium isolates carried the vanB gene. Among virulence genes investigated, the esp was found in 27(71%) VREfm strains, but did not in any VREfs. Other virulence determinants were highly detected in VREfs strains. Our data indicate a high prevalence of E. faecium harboring vancomycin resistance with vanA genotype and the two VRE species displayed different virulence genes.
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