ReviewApplied and environmental microbiology2012
Epoxy Coenzyme A Thioester pathways for degradation of aromatic compounds.
Review in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
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- Diversity of estrogen biodegradation pathways and application in environmental bioremediation.Frontiers in microbiology · 2025Review
- A Novel Coenzyme A Analogue in the Anaerobic, Sulfate-Reducing, Marine Bacterium Desulfobacula toluolica Tol2Chembiochem : a European journal of chemical biology · 2023Article
- Insights into the global freshwater virome.Frontiers in microbiology · 2022Article
- Isolation and characterization of a halophilic Modicisalibacter sp. strain Wilcox from produced water.Scientific reports · 2021Article
- Statistical optimisation of growth conditions and diesel degradation by the Antarctic bacterium, Rhodococcus sp. strain AQ5‒07.Extremophiles : life under extreme conditions · 2020Article
- Genomic analysis ofBiotechnology for biofuels · 2019Article
- Enrichment of Bacteria From Eastern Mediterranean Sea Involved in Lignin Degradation via the Phenylacetyl-CoA Pathway.Frontiers in microbiology · 2018Article
- Biotechnological Applications of Microbial (Per)chlorate Reduction.Microorganisms · 2017Review
- Enhancing methyl parathion degradation by the immobilization of Burkholderia sp. isolated from agricultural soils.MicrobiologyOpen · 2017Article
- Functional Gene Diversity and Metabolic Potential of the Microbial Community in an Estuary-Shelf Environment.Frontiers in microbiology · 2017Article
- Article
- Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium- and long-chain acyl-coenzyme A thioesters.Rapid communications in mass spectrometry : RCM · 2014Article
- New hydrocarbon degradation pathways in the microbial metagenome from Brazilian petroleum reservoirs.PloS one · 2014Article
- An oxygenase-independent cholesterol catabolic pathway operates under oxic conditions.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aromatic compounds (biogenic and anthropogenic) are abundant in the biosphere. Some of them are well-known environmental pollutants. Although the aromatic nucleus is relatively recalcitrant, microorganisms have developed various catabolic routes that enable complete biodegradation of aromatic compounds. The adopted degradation pathways depend on the availability of oxygen. Under oxic conditions, microorganisms utilize oxygen as a cosubstrate to activate and cleave the aromatic ring. In contrast, under anoxic conditions, the aromatic compounds are transformed to coenzyme A (CoA) thioesters followed by energy-consuming reduction of the ring. Eventually, the dearomatized ring is opened via a hydrolytic mechanism. Recently, novel catabolic pathways for the aerobic degradation of aromatic compounds were elucidated that differ significantly from the established catabolic routes. The new pathways were investigated in detail for the aerobic bacterial degradation of benzoate and phenylacetate. In both cases, the pathway is initiated by transforming the substrate to a CoA thioester and all the intermediates are bound by CoA. The subsequent reactions involve epoxidation of the aromatic ring followed by hydrolytic ring cleavage. Here we discuss the novel pathways, with a particular focus on their unique features and occurrence as well as ecological significance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.