ArticleFrontiers in systems neuroscience2012
Psychophysical properties of odor processing can be quantitatively described by relative action potential latency patterns in mitral and tufted cells.
Article in Frontiers in systems neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation.Nature neuroscience · 2026Article
- Firing Patterns of Mitral Cells and Their Transformation in the Main Olfactory Bulb.Brain sciences · 2024Article
- Time Is of the Essence: Neural Codes, Synchronies, Oscillations, Architectures.Frontiers in computational neuroscience · 2022Article
- Odor coding in piriform cortex: mechanistic insights into distributed coding.Current opinion in neurobiology · 2020Review
- Primacy coding facilitates effective odor discrimination when receptor sensitivities are tuned.PLoS computational biology · 2019Article
- Article
- Recurrent cortical circuits implement concentration-invariant odor coding.Science (New York, N.Y.) · 2018Article
- High Precision of Spike Timing across Olfactory Receptor Neurons Allows Rapid Odor Coding in Drosophila.iScience · 2018Article
- Article
- A primacy code for odor identity.Nature communications · 2017Article
- Article
- Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding.PloS one · 2015Article
- From molecule to mind: an integrative perspective on odor intensity.Trends in neurosciences · 2014Review
- Greater excitability and firing irregularity of tufted cells underlies distinct afferent-evoked activity of olfactory bulb mitral and tufted cells.The Journal of physiology · 2014Article
- Characterizing olfactory perceptual similarity using carbon chain discrimination in Fischer 344 rats.Chemical senses · 2014Article
- A spiking neural network model of self-organized pattern recognition in the early mammalian olfactory system.Frontiers in neural circuits · 2014Article
- Multiple modes of phase locking between sniffing and whisking during active exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neural variability, or lack thereof.Frontiers in computational neuroscience · 2013Article
- Chemosensory learning and memory.Frontiers in systems neuroscience · 2012Article
- Article
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2 authors.
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Abstract
Electrophysiological and population imaging data in rodents show that olfactory bulb (OB) activity is profoundly modulated by the odor sampling process while behavioral experiments indicate that odor discrimination can occur within a single sniff. This paper addresses the question of whether action potential (AP) latencies occurring across the mitral and tufted cell (M/TC) population within an individual sampling cycle could account for the psychophysical properties of odor processing. To determine this we created an OB model (50,000 M/TCs) exhibiting hallmarks of published in vivo properties and used a template-matching algorithm to assess stimulus separation. Such an AP latency-based scheme showed high reproducibility and sensitivity such that odor stimuli could be reliably separated independent of concentration. As in behavioral experiments we found that very dissimilar odors ("A vs. B") were accurately and rapidly discerned while very similar odors (binary mixtures, 0.4A/0.6B vs. 0.6A/0.4B) required up to 90 ms longer. As in lesion studies we find that AP latency-based representation is rather insensitive to disruption of large regions of the OB. The AP latency-based scheme described here, therefore, captures both temporal and psychophysical properties of olfactory processing and suggests that the onset patterns of M/TC activity in the OB represent stimulus specific features of olfactory stimuli.
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