Evidence map›Paper›PMID 22582036›Full record

ArticleCurrent hypertension reviews2011

Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models.

Natalie O Karpinich, Samantha L Hoopes, Daniel O Kechele, Patricia M Lenhart, Kathleen M Caron

Open access · greenAbstract read
In one paragraph

Article in Current hypertension reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Influence of adrenomedullin on the enzymatic activity of dipeptidyl peptidase 3Journal of enzyme inhibition and medicinal chemistry · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Adrenomedullin as an Immunomodulator of CD14Journal of clinical and translational hepatology · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Endothelial deletion ofbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Review
  15. Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Review
  16. Review
  17. Article
  18. Circulating MR-proADM levels, as an indicator of endothelial dysfunction, for early risk stratification of mid-term mortality in COVID-19 patients.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Observational
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Natalie O KarpinichDepartment of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Samantha L Hoopes
Daniel O Kechele
Patricia M Lenhart
Kathleen M Caron
Institute of Cell Biology and Neurobiology · ITUniversity of North Carolina at Chapel Hill · US

Funding

Adrenomedullin Signaling at the Maternal-Fetal InterfaceR01HD060860 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron · 2009 to 2026
$4.8M
Adrenomedullin Signaling in Vascular DevelopmentR01HL091973 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARON, KATHLEEN M · 2008 to 2011
$1.4M
NHLBI NIH HHS R01 HL091973NICHD NIH HHS R01 HD060860
6 · The paper itself

Abstract

Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.

Identifiers

PMID22582036
PMCPMC3349984
OpenAlexW2116447180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.