ReviewCirculation research2012
Cardiac side population cells: moving toward the center stage in cardiac regeneration.
Review in Circulation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Cancer stem cells: advances in knowledge and implications for cancer therapy.Signal transduction and targeted therapy · 2024Review
- The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression.Life (Basel, Switzerland) · 2023Review
- Cardiac Progenitor Cells.Advances in experimental medicine and biology · 2021Review
- Ivabradine-Stimulated Microvesicle Release Induces Cardiac Protection against Acute Myocardial Infarction.International journal of molecular sciences · 2020Article
- Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Stem cell therapy of myocardial infarction: a promising opportunity in bioengineering.Advanced therapeutics · 2020Article
- Cardiac stem cells for myocardial regeneration: promising but not ready for prime time.Current opinion in biotechnology · 2017Review
- Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?Journal of cardiovascular translational research · 2016Review
- The Role of Cardiac Side Population Cells in Cardiac Regeneration.Frontiers in cell and developmental biology · 2016Review
- Pharmacological inhibition of TGFβ receptor improves Nkx2.5 cardiomyoblast-mediated regeneration.Cardiovascular research · 2015Article
- Incorporation of gold-coated microspheres into embryoid body of human embryonic stem cells for cardiomyogenic differentiation.Tissue engineering. Part A · 2015Article
- Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects.Biomarker insights · 2015Review
- Cardiac stem cells: biology and clinical applications.Antioxidants & redox signaling · 2014Review
- Redox signaling in cardiac renewal.Antioxidants & redox signaling · 2014Review
- Human heart failure: is cell therapy a valid option?Biochemical pharmacology · 2014Review
- Gradient static-strain stimulation in a microfluidic chip for 3D cellular alignment.Lab on a chip · 2014Article
- Microfluidics-assisted fabrication of gelatin-silica core-shell microgels for injectable tissue constructs.Biomacromolecules · 2014Article
- Stem cell therapy for cardiac dysfunction.SpringerPlus · 2014Review
- Pregnancy-induced physiological hypertrophy protects against cardiac ischemia-reperfusion injury.International journal of clinical and experimental pathology · 2014Article
- Optimised protocols for the identification of the murine cardiac side population.Stem cell reviews and reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Over the past decade, extensive work in animal models and humans has identified the presence of adult cardiac progenitor cells, capable of cardiomyogenic differentiation and likely contributors to cardiomyocyte turnover during normal development and disease. Among cardiac progenitor cells, there is a distinct subpopulation, termed "side population" (SP) progenitor cells, identified by their unique ability to efflux DNA binding dyes through an ATP-binding cassette transporter. This review highlights the literature on the isolation, characterization, and functional relevance of cardiac SP cells. We review the initial discovery of cardiac SP cells in adult myocardium as well as their capacity for functional cardiomyogenic differentiation and role in cardiac regeneration after myocardial injury. Finally, we discuss recent advances in understanding the molecular regulators of cardiac SP cell proliferation and differentiation, as well as likely future areas of investigation required to realize the goal of effective cardiac regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.