ArticleReproductive sciences (Thousand Oaks, Calif.)2012
Elevated prevalence of 35-44 FMR1 trinucleotide repeats in women with diminished ovarian reserve.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does theFMR1 gene affect IVF success?Reproductive biomedicine online · 2019Pooled it
- Genetic associations with diminished ovarian reserve: a systematic review of the literature.Journal of assisted reproduction and genetics · 2014Pooled it
- The polygenic score for age at menopause is independently associated with the response of controlled ovarian hyperstimulation in women undergoing IVF.EBioMedicine · 2026Article
- Article
- The association of CGG repeat length and AGG interruption patterns on FMR1 alleles with female infertility.Frontiers in endocrinology · 2025Article
- Perspectives on biomarkers of reproductive aging for fertility and beyond.Nature aging · 2024Review
- Advances in the genetic etiology of female infertility.Journal of assisted reproduction and genetics · 2024Review
- Review
- Asian Americans and infertility: genetic susceptibilities, sociocultural stigma, and access to care.F&S reports · 2022Article
- Article
- Mechanisms of ovarian aging.Reproduction (Cambridge, England) · 2021Review
- The significance of FMR1 CGG repeats in Chinese women with premature ovarian insufficiency and diminished ovarian reserve.Reproductive biology and endocrinology : RB&E · 2020Article
- Characterization of the Metabolic, Clinical and Neuropsychological Phenotype of Female Carriers of the Premutation in the X-LinkedFrontiers in molecular biosciences · 2020Article
- Defining the role of FMR1 gene in unexplained recurrent spontaneous abortion.Journal of assisted reproduction and genetics · 2019Article
- Apoptosis of mural granulosa cells is increased in women with diminished ovarian reserve.Journal of assisted reproduction and genetics · 2019Article
- FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve.Reproductive biology and endocrinology : RB&E · 2018Article
- Effect of race and ethnicity on utilization and outcomes of assisted reproductive technology in the USA.Reproductive biology and endocrinology : RB&E · 2017Article
- Distribution of the FMR1 gene in females by race/ethnicity: women with diminished ovarian reserve versus women with normal fertility (SWAN study).Fertility and sterility · 2017Article
- Review
- Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause.Human reproduction (Oxford, England) · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionFragile X premutations are associated with primary ovarian insufficiency when the patient presents with amenorrhea, but the fragile X mental retardation 1 (FMR1) CGG repeat count among cycling women with low ovarian reserve (diminished ovarian reserve [DOR]) is not yet established. PATIENTS AND
methodsSixty-two infertile DOR patients were recruited from 4 US private and academic fertility centers.
resultsThe prevalence of 35-44 FMR1 CGG repeats was 14.5%. Compared with the general female population estimate from the literature, infertile women with DOR were more likely to have 35-44 FMR1 CGG repeats (14.5% and 3.9%, respectively, P = .0003). Similar findings were noted by 5-repeat bandwidth: 35-39 CGG repeats (9.7% DOR vs 3.2% comparison, P = .012) or 40-44 CGG repeats (4.8% DOR vs 0.7% comparison, P = .024).
conclusionsThese data suggest that CGG repeats of 35-44 may be markedly overrepresented in women with DOR, whereas the current FMR1 reference range indicates that there is no clinical phenotype with <45 CGG repeats.
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