ReviewWiley interdisciplinary reviews. Systems biology and medicine
Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Challenges and Opportunities in Multi-Omics Data Acquisition and Analysis: Toward Integrative Solutions.Biomolecules · 2026Review
- Pharmacogenomics-guided therapy for essential hypertension: a multi-center randomized controlled open-label trial.Frontiers in cardiovascular medicine · 2026Article
- Review
- Can Systems Biology Advance Clinical Precision Oncology?Cancers · 2021Review
- Systems Biology and Experimental Model Systems of Cancer.Journal of personalized medicine · 2020Review
- Identification of key genes for guiding chemotherapeutic management in ovarian cancer using translational bioinformatics.Oncology letters · 2020Article
- A systems approach to clinical oncology uses deep phenotyping to deliver personalized care.Nature reviews. Clinical oncology · 2020Review
- The application of big data to cardiovascular disease: paths to precision medicine.The Journal of clinical investigation · 2020Review
- Biomarker definitions and their applications.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Personalized medicine-a modern approach for the diagnosis and management of hypertension.Clinical science (London, England : 1979) · 2017Review
- Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.Frontiers in pharmacology · 2017Article
- Precision medicine in cardiology.Nature reviews. Cardiology · 2016Review
- Improved prediction of complex diseases by common genetic markers: state of the art and further perspectives.Human genetics · 2016Review
- Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015.Journal of the American Heart Association · 2015Article
- Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.Circulation · 2015Article
- Genetics and the placebo effect: the placebome.Trends in molecular medicine · 2015Review
- Systems biology for molecular life sciences and its impact in biomedicine.Cellular and molecular life sciences : CMLS · 2013Review
- Are randomized trials obsolete or more important than ever in the genomic era?Genome medicine · 2013Article
- The emerging paradigm of network medicine in the study of human disease.Circulation research · 2012Review
- Systems medicine: evolution of systems biology from bench to bedside.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The rapidly growing disciplines of systems biology and network science are now poised to meet the fields of clinical medicine and pharmacology. Principles of systems pharmacology can be applied to drug design and, ultimately, testing in human clinical trials. Rather than focusing exclusively on single drug targets, systems pharmacology examines the holistic response of a phenotype-dependent pathway or pathways to drug perturbation. Knowledge of individual pharmacogenetic profiles further modulates the responses to these drug perturbations, moving the field toward more individualized ('personalized') drug development. The speed with which the information required to assess these system responses and their genomic underpinnings is changing and the importance of identifying the optimal drug or drug combinations for maximal benefit and minimal risk require that clinical trial design strategies be adaptable. In this paper, we review the tenets of adaptive clinical trial design as they may apply to an era of expanding knowledge of systems pharmacology and pharmacogenomics, and clinical trail design in network medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.